The high cost of building materials, especially sandcrete blocks in Ghana, has made building construction products expensive and created a housing deficit of about 1.6 million. Meanwhile, the interlocking blocks, which are made up of laterite and cement abound could be exploited to help reduce the cost of housing construction. Especially, wall construction which is one of the major components of the entire building process. This paper sought to explore the possibility of adopting the interlocking block wall system as a means of making wall construction of buildings affordable in Ghana. A comparative study using interlocking blocks system and sandcrete blocks was made. An observation of the processes were made to identify the extent to which each system falls in line. A sample size of 45 respondents comprising 20 workers of P-A Capital Estate Housing, 5 personnel from consultancy firms and 20 private individuals were selected for further confirmatory study with the use of convenience and purposive sampling technique. To determine whether there were any statistically significant differences between the mean values, paired-sample t-test at the 0.05 level of significance was done. Results showed that, the use of interlocking blocks do not only lead to elimination of a number of non-value adding activities associated with the use of the sandcrete blocks, but also make the wall construction process cheaper and faster. It was also discovered that the absence of mortar jointing in the interlocking system reduced the quantity of materials, like cement and sand, required in the sandcrete wall construction process. Furthermore, there was no statistically difference between the compressive strength of interlocking blocks and conventional sandcrete blocks. However, there were statistically significant differences between construction cost and speed of construction using the two systems of construction.
