The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments

Magnusson, Patrik K. E.; Almqvist, Catarina; Rahman, Iffat; Ganna, Andrea; Viktorin, Alexander; Walum, Hasse; Halldner, Linda; Lundström, Sebastian; Ullén, Fredrik; Långström, Niklas; Larsson, Henrik; Nyman, Anastasia; Gumpert, Clara Hellner; Råstam, Maria; Anckarsäter, Henrik; Cnattingius, Sven; Johannesson, Magnus; Klareskog, Lars; Fairé, Ulf dé; Pedersen, Nancy L.; Lichtenstein, Paul

doi:10.1017/thg.2012.104

Cited by 289 publications

(306 citation statements)

References 41 publications

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“…Using the Illumina 450K array, DNA methylation data of 390,894 autosomal CpGs were obtained from 385 twins (73 MZ, 96 DZ complete twin pairs) enrolled in the Swedish Adoption/Twin Study of Aging (SATSA) [16] (Table 1), which is part of the Swedish Twin Registry [17]. The longitudinal EWAS analysis revealed systematic changes of methylation with age.…”

Section: Resultsmentioning

confidence: 99%

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Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

et al. 2018

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Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3×10−7) using a longitudinal epigenome-wide association study design. We measured how estimated cellular compositions changed with age and how much they confounded the age effect. We validated the results in two independent longitudinal cohorts, where 118 CpGs were replicated in Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, 390 samples) (P<3.9×10−5), 594 in Lothian Birth Cohort (LBC, 3018 samples) (P<5.1×10−5) and 63 in both. Functional annotation of age-associated CpGs showed enrichment in CCCTC-binding factor (CTCF) and other transcription factor binding sites. We further investigated genetic influences on methylation and found no interaction between age and genetic effects in the 1316 age-associated CpGs. Moreover, in the same CpGs, methylation differences within twin pairs increased with 6.4% over 10 years, where monozygotic twins had smaller intra-pair differences than dizygotic twins. In conclusion, we show that age-related methylation changes persist in a longitudinal perspective, and are fairly stable across cohorts. The changes are under genetic influence, although this effect is independent of age. Moreover, methylation variability increase over time, especially in age-associated CpGs, indicating the increase of environmental contributions on DNA methylation with age.

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Section: Resultsmentioning

confidence: 99%

“…The SATSA is part of the Swedish Twin Registry (STR) [17], which is a population-based national register including twins born 1886-2000. The SATSA started in 1984, and continuously collected cognitive and health data every third year with up to ten waves in a total of 861 participants.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

et al. 2018

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“…The data were retrieved from SATSA (22), which originates from the population-based Swedish Twin Registry (STR) (23). Participants in SATSA are part of both the old cohort (born 1886-1925) and middle cohort (born 1926-1958) in the STR.…”

Section: Measurementsmentioning

confidence: 99%

Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging

Ericsson

Lundholm

Fors

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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In this report we analyzed genetically informative data to investigate within-person change and between-person differences in late-life cognitive abilities as a function of childhood social class. We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Aging and parental social class based on the Swedish socioeconomic index. Cognitive ability included a general factor and the four domains of verbal, fluid, memory, and perceptual speed. Latent growth curve models of the longitudinal data tested whether level and change in cognitive performance differed as a function of childhood social class. Between-within twin-pair analyses were performed on twins reared apart to assess familial confounding. Childhood social class was significantly associated with mean-level cognitive performance at age 65 y, but not with rate of cognitive change. The association decreased in magnitude but remained significant after adjustments for level of education and the degree to which the rearing family was supportive toward education. A between-pair effect of childhood social class was significant in all cognitive domains, whereas within-pair estimates were attenuated, indicating genetic confounding. Thus, childhood social class is important for cognitive performance in adulthood on a population level, but the association is largely attributable to genetic influences. childhood social class | cognitive aging | adoption | twins

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“…Data were collected as part of a web survey sent out to a cohort of approximately 32 000 twins born between 1959 and 1985 – the STAGE cohort 21 – part of the Swedish Twin Registry (STR), one of the largest registries of its kind 22, 23. In total, 11 543 individuals participated in the web survey.…”

Section: Introductionmentioning

confidence: 99%

Predictors of continued playing or singing – from childhood and adolescence to adult years

et al. 2015

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AimMany individuals play an instrument or sing during childhood, but they often stop later in life. This study surveyed adults representative of the Swedish population about musical activities during childhood.MethodsWe asked 3820 adults (65% women) aged from 27 to 54 from the Swedish Twin Registry, who took extra music lessons to those provided at school, to fill in a web‐based questionnaire. Factors analysed were the age they started studying music, the instrument they played, kind of teaching, institution and educational content, number of lessons and perceived characteristics of the lessons, the music environment during their childhood years and their preferred music genre. All variables were dichotomised.ResultsFactors strongly associated with continued playing or singing were male sex, young starting age, cultural family background, self‐selected instrument, attending music classes and more than once a week, church‐related or private education, pop, rock or classical music, playing by ear and improvisation.ConclusionSeveral significant predictors determined whether a child continued to sing or play an instrument as an adult and many could be externally influenced, such as starting at a young age, taking music classes more than once a week, improvisation and the type of music they played.

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The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments

Cited by 289 publications

References 41 publications

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging

Predictors of continued playing or singing – from childhood and adolescence to adult years

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