The sweet tooth of the circadian clock

Fu, Minnie; Yang, Xiaoyong

doi:10.1042/bst20160183

Cited by 8 publications

(4 citation statements)

References 136 publications

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“…O-GlcNAcylation of cellular protein is sensitive to nutrient input [25, 49]. Since we observed that PER O-GlcNAcylation is higher during the day and gradually decreases over the circadian cycle, we expect that this temporal pattern may correlate to daily feeding activity.…”

Section: Resultsmentioning

confidence: 96%

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

Liu

Vanselow

et al. 2019

PLoS Genet

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Circadian clocks coordinate time-of-day-specific metabolic and physiological processes to maximize organismal performance and fitness. In addition to light and temperature, which are regarded as strong zeitgebers for circadian clock entrainment, metabolic input has now emerged as an important signal for clock entrainment and modulation. Circadian clock proteins have been identified to be substrates of O-GlcNAcylation, a nutrient sensitive post-translational modification (PTM), and the interplay between clock protein O-GlcNAcylation and other PTMs is now recognized as an important mechanism by which metabolic input regulates circadian physiology. To better understand the role of O-GlcNAcylation in modulating clock protein function within the molecular oscillator, we used mass spectrometry proteomics to identify O-GlcNAcylation sites of PERIOD (PER), a repressor of the circadian transcriptome and a critical biochemical timer of the Drosophila clock. In vivo functional characterization of PER O-GlcNAcylation sites indicates that O-GlcNAcylation at PER(S942) reduces interactions between PER and CLOCK (CLK), the key transcriptional activator of clock-controlled genes. Since we observe a correlation between clock-controlled daytime feeding activity and higher level of PER O-GlcNAcylation, we propose that PER(S942) O-GlcNAcylation during the day functions to prevent premature initiation of circadian repression phase. This is consistent with the period-shortening behavioral phenotype of per (S942A) flies. Taken together, our results support that clock-controlled feeding activity provides metabolic signals to reinforce light entrainment to regulate circadian physiology at the post-translational level. The interplay between O-GlcNAcylation and other PTMs to regulate circadian physiology is expected to be complex and extensive, and reach far beyond the molecular oscillator.

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Section: Resultsmentioning

confidence: 96%

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

Liu

Vanselow

et al. 2019

PLoS Genet

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“…31 Another metabolism-related PTM includes protein O-GlcNAcylation, which has been reported to be circadian regulated in various tissues, including the heart. 55,176 Evidence suggests that BMAL1, CLOCK, PER1/2, and CRY1/2 are all O-GlcNAc modified, affecting their stability, cellular locality, and activity. 176 In the case of BMAL1, 24-hour rhythms in protein O-GlcNAcylation peak in the heart during the active period.…”

Section: Metabolism As An Integral Circadian Clock Feedback Loopmentioning

confidence: 99%

“…55,176 Evidence suggests that BMAL1, CLOCK, PER1/2, and CRY1/2 are all O-GlcNAc modified, affecting their stability, cellular locality, and activity. 176 In the case of BMAL1, 24-hour rhythms in protein O-GlcNAcylation peak in the heart during the active period. 55 Moreover, pharmacological perturbation of cardiac O-GlcNAcylation results in a rapid phase shift of the heart clock, consistent with a functional consequence of the PTM on the clock mechanism.…”

Section: Metabolism As An Integral Circadian Clock Feedback Loopmentioning

confidence: 99%

Circadian Rhythms in Cardiovascular Metabolism

Lal,

Verma,

Wang

et al. 2024

Circulation Research

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Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become increasingly clear is that in addition to classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks to temporally orchestrate metabolic pathways in preparation for predicted stimuli/stresses (termed anticipatory mechanisms). Here, we review current knowledge regarding circadian regulation of metabolism, how metabolic rhythms are synchronized with cardiovascular function, and whether circadian misalignment/disruption of metabolic processes contribute toward the pathogenesis of cardiovascular disease.

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“…CRY and PER accumulate and form a dimer (CRY:PER) that inhibits CLOCK:BMAL1 activity. Adapted from [92]…”

Section: Introductionmentioning

confidence: 99%

Chronodentistry: the role & potential of molecular clocks in oral medicine

Janjić

Agis

2019

BMC Oral Health

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Molecular clocks help organisms to adapt important physiological functions to periodically changing conditions in the environment. These include the adaption of the 24 h sleep-wake rhythm to changes of day and night. The circadian clock is known to act as a key regulator in processes of health and disease in different organs. The knowledge on the circadian clock led to the development of chronopharmacology and chronotherapy. These fields aim to investigate how efficiency of medication and therapies can be improved based on circadian clock mechanisms. In this review we aim to highlight the role of the circadian clock in oral tissues and its potential in the different fields of dentistry including oral and maxillofacial surgery, restorative dentistry, endodontics, periodontics and orthodontics to trigger the evolving field of chronodentistry.

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The sweet tooth of the circadian clock

Cited by 8 publications

References 136 publications

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

Circadian Rhythms in Cardiovascular Metabolism

Chronodentistry: the role & potential of molecular clocks in oral medicine

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