The swelling behaviour of thermoresponsive hydrogel/silica nanoparticle composites

Brom, Coenraad R. van den; Anac, Ilke; Roskamp, Robert F.; Retsch, Markus; Jonas, Ulrich; Menges, Bernhard; Preece, Jon A.

doi:10.1039/b927314j

Cited by 42 publications

(23 citation statements)

References 58 publications

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“…It seems that if we could use pH- or temperature- sensitive crosslinkers as glue, we could break the links and change NP shape upon activation by pH or temperature. For example, a new responsive nanocomposite material consisting of a poly-( N -isopropylacrylamide) hydrogel and ‘super-crosslinking’ silica NPs has been synthesized [104] by mixing both components in a solution, followed by spin coating on a thin film and photocrosslinking by UV irradiation. We should also consider shape-changing NPs be triggered enzymatically by the disease condition, leading towards better cellular uptake and enhanced drug dispersion.…”

Section: Future Perspectivementioning

confidence: 99%

The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery

Liu

Tan

Thomas

et al. 2012

Therapeutic Delivery

241

133

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The design of nanoparticle (NP) size, shape and surface chemistry has a significant impact on their performance. While the influences of the particle size and surface chemistry on drug delivery have been studied extensively, little is known about the effect of particle shapes on nanomedicine. In this perspective article, we discuss recent progress on the design and fabrication of NPs of various shapes and their unique delivery properties. The shapes of these drug carriers play an important role in therapeutic delivery processes, such as particle adhesion, distribution and cell internalization. We envision that stimuli-responsive NPs, which actively change their shapes and other properties, might pave way to the next generation of nanomedicine.

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Section: Future Perspectivementioning

confidence: 99%

The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery

Liu

Tan

Thomas

et al. 2012

Therapeutic Delivery

241

133

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“…The equilibrium responsive properties of cross-linked pNIPAAm layers were extensively studied as a function of slow-temperature variations depending on the network density, solvent, and polymer backbone modifications. 8,16,17 …”

Section: Introductionmentioning

confidence: 99%

Active Control of SPR by Thermoresponsive Hydrogels for Biosensor Applications

et al. 2013

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The use of thermoresponsive poly(N-isopropylacrylamide)-based hydrogel (pNIPAAm) for rapid tuning of surface plasmon resonance (SPR) is reported. This approach is implemented by using an SPR layer architecture with an embedded indium tin oxide microheater and pNIPAAm film on its top. It takes advantage of rapid thermally induced swelling and collapse of pNIPAAm that is accompanied by large refractive index changes and leads to high thermo-optical coefficient of dn/dT = 2 × 10–2 RIU/K. We show that this material is excellently suited for efficient control of refractive index-sensitive SPR and that it can serve simultaneously as a 3D binding matrix in biosensor applications (if modified with biomolecular recognition elements for a specific capture of target analyte). We demonstrate that this approach enables modulating of the output signal in surface plasmon-enhanced fluorescence spectroscopy biosensors and holds potential for simple time-multiplexing of sensing channels for parallelized readout of fluorescence assays.

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“…In contrast, the swelling percentages in all MF‐Lip@PEG groups were noticeably lower, ranging from ≈900% for both MF‐Lip20@PEG and MF‐Lip10@PEG to just 800% for MF‐Lip40@PEG. Increasing amounts of MF‐Lip were added to the hydrogel system, leading to a denser network structure in the composite hydrogels, and resulting in lower swelling percentages and longer endurance periods of the MF‐Lip40@PEG, because the dense network could serve as a barrier to the movement of water molecules …”

Section: Methodsmentioning

confidence: 99%

Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration

et al. 2018

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The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing–promoting properties that match the dynamic healing process of skin flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF‐Lip@PEG) is developed for clinical applications through Ag–S coordination of four‐arm‐PEG‐SH and Ag+. Compared to MF‐PEG, MF‐Lip@PEG exhibits self‐healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization‐promoting effect. The MF‐Lip@PEG also exhibits a strong cytoprotective effect against hypoxia‐induced apoptosis through regulation of the Bax/Bcl‐2/caspase‐3 pathway. In a random skin flap animal model, the MF‐Lip@PEG is injectable and convenient to deliver into the skin flap, providing excellent anti‐inflammation, anti‐infection, and proneovascularization effects and significantly reducing the skin flap necrosis rate. In general, the MF‐Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of skin flap regeneration.

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The swelling behaviour of thermoresponsive hydrogel/silica nanoparticle composites

Cited by 42 publications

References 58 publications

The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery

The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery

Active Control of SPR by Thermoresponsive Hydrogels for Biosensor Applications

Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration

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