The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD

Seo, Seongjin; Richardson, Genova A.; Kroll, Kristen L.

doi:10.1242/dev.01548

Cited by 179 publications

(189 citation statements)

References 56 publications

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“…Taken together, these provide compelling evidence for tissue-specific and stage-specific roles for different chromatinremodeling complexes. In support of this conclusion, expression in the mouse of several different chromatin remodeling complex factors also demonstrated neural-specific expression patterns during development (Olave et al, 2002;Seo et al, 2005). However, the targeted disruption of Brg1 in the mouse led to lethality in the preimplantation embryo, precluding analysis of a potential role in neural development (Bultman et al, 2000).…”

Section: Morphological Screensmentioning

confidence: 79%

Zebrafish: A model system for the study of eye genetics

Fadool

Dowling

2008

Progress in Retinal and Eye Research

195

172

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Over the last decade, the use of the zebrafish as a genetic model has moved beyond the proof-ofconcept for the analysis of vertebrate embryonic development to demonstrated utility as a mainstream model organism for the understanding of human disease. The initial identification of a variety of zebrafish mutations affecting the eye and retina, and the subsequent cloning of mutated genes have revealed cellular, molecular and physiological processes fundamental to visual system development. With the increasing development of genetic manipulations, sophisticated techniques for phenotypic characterization, behavioral approaches and screening strategies, the identification of novel genes or novel gene functions will have important implications for our understanding of human eye diseases, pathogenesis, and treatment.

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Section: Morphological Screensmentioning

confidence: 79%

Zebrafish: A model system for the study of eye genetics

Fadool

Dowling

2008

Progress in Retinal and Eye Research

195

172

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“…Unfortunately, the functions of serine/threonine kinases in this subfamily are not known yet (Stopka and Skoultchi, 2003). However, several reports suggest that the AGC group of serine/threonine kinases play roles in controlling cell proliferation, differentiation, morphology, and migration; the AGC group is closely related to the SNF1 subfamily (Reyes et al, 1998;Stopka and Skoultchi, 2003;Stephenson et al, 2004;Seo et al, 2005;Young et al, 2005). Particularly RockI and RockII of this group are Rho effectors and play important roles in cell morphology and behavior (Riento and Ridley, 2003); the small GTPase Rho regulates several steps of actin dynamics (EtienneManneville and Hall, 2002).…”

Section: Omphk1 Mutant Phenotypementioning

confidence: 99%

A new serine/threonine protein kinase,Omphk1, essential to ventral body wall formation

Hirano¹,

Kanazawa

Furushima

et al. 2006

Developmental Dynamics

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Here, we report a new serine/threonine protein kinase of the SNF1 subfamily Omphk1. Two Omphk homologues exist in each vertebrate species, and one homologue exists in Drosophila and Caenorhabditis elegans; the kinase domain is highly conserved among these homologues, and several domains are conserved among vertebrate Omphk. Omphk1 expression dynamically changes in the developing central nervous system, is found ubiquitously in epidermis, and is present uniquely in several other tissues. Its expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall. Concomitantly, its null mutant exhibits omphalocele with a failure in closure of the secondary body wall. There are no apparent gross morphological defects in brain, however, despite the unique Omphk1 expression in this tissue.

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“…Furthermore, mutations in BAF155, a subunit that has been proposed to shield BAF complexes from proteosomal degradation and promote the nuclear localization of the complex, similarly result in peri-implantation lethality and neural tube defects (Kim et al, 2001;Sohn et al, 2007). Unlike Brg1 inactivation in Xenopus, which promotes the expansion of neural progenitors (Seo et al, 2005), Brg1 inactivation in vertebrates was shown to interfere with neural progenitor selfrenewal and results in the eventual loss of neural progenitor populations (Matsumoto et al, 2006;Lessard et al, 2007). Therefore, it can be inferred that BAF complexes function during early neurodevelopment to promote maintenance and differentiation of neural progenitors, thereby allowing for proper neural tube formation.…”

Section: Impact Of Chromatin Remodeling On Neural Developmentmentioning

confidence: 99%

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

Maze

Noh

Allis

2012

Neuropsychopharmacol

117

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Postmitotic neurons are subject to a vast array of environmental influences that require the nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic states associated with synaptic function, circuit formation, and behavioral memory. Over the last decade, much attention has been paid to the roles of transcription and chromatin regulation in guiding fundamental aspects of neuronal function. A great deal of this work has centered on neurodevelopmental and adulthood plasticity, with increased focus in the areas of neuropharmacology and molecular psychiatry. Here, we attempt to provide a broad overview of chromatin regulation, as it relates to central nervous system (CNS) function, with specific emphasis on the modes of histone posttranslational modifications, chromatin remodeling, and histone variant exchange. Understanding the functions of chromatin in the context of the CNS will aid in the future development of pharmacological therapeutics aimed at alleviating devastating neurological disorders.

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The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD

Cited by 179 publications

References 56 publications

Zebrafish: A model system for the study of eye genetics

Zebrafish: A model system for the study of eye genetics

A new serine/threonine protein kinase,Omphk1, essential to ventral body wall formation

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

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