The sympathetic nervous system's role in regulating blood pressure variability

Malpas, Simon C.; Leonard, Bridget L.; Guild, Sarah-Jane; Ringwood, John V.; Navakatikyan, Michael A.; Austin, P.C.; Head, Geoffrey A.; Burgess, Don E.

doi:10.1109/51.917720

Cited by 26 publications

(25 citation statements)

References 60 publications

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“…It provides one of the fundamental mechanisms for the control of blood flow and blood pressure [20,21]. These fundamental mechanisms seem to be annulled in microcirculation of malignant tumors and there they seem to be similar to those of free microvascular flaps [28].…”

Section: Discussionmentioning

confidence: 99%

Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior

Häfner

Bräuer

Radke

et al. 2009

Clinical Hemorheology and Microcirculation

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We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis.A total of 68 patients with primary BCCs and 40 patients with PP were included in the study. LDF time series were separated in four scaling levels corresponding to the influences of sympathetic activity (SL1), myogenic activity in the vessel wall (SL2), respiration (SL3) and heart beat (SL4).In BCC, SL1 decreased compared to healthy skin. In all other scaling levels, we found a statistically significant increase of the SLs compared to healthy skin. These increases were not found in PP.Rhythmical behavior of blood flow in malignant tumors is totally different from that in regions with inflammation. In BCCs, thermoregulatory processes, ascribed to sympathetic activity, decrease statistically significant. In contrast, inflammatory processes in PP do not substantially change sympathetic activity. WA of tumor perfusion could open a new noninvasive monitor system for controlling tumor therapy.

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Section: Discussionmentioning

confidence: 99%

Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior

Häfner

Bräuer

Radke

et al. 2009

Clinical Hemorheology and Microcirculation

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“…In this study, we determined how heat-induced pain (external stimuli) affected peripheral vasoconstriction. Based on our understanding of the physiology regulating FBV, the proposed model (Fig 1) consisted of 4 components: 1) blood pressure coupling (BPC): blood pressure affects ΔFBV through sympathetically-mediated baroreflex control of peripheral resistance [16] as well as through local regulation of blood flow [17,18]; 2) respiratory coupling (RPC): respiration is known to modulate sympathetic neural activity [19,20] and changes in breathing induced by pain, e.g. sighs and breath holds, may elicit changes in peripheral resistance [3,21]; 3) neurogenic thermal pain coupling (THM): heat-induced pain affected ΔFBV through sympathetic modulation directly as well as through its modulation on MAP and V T ; and 4) the neurogenic-vascular interaction (BPCTHM): the interaction effect between ΔMAP and ΔTemp on ΔFBV.…”

Section: Methodsmentioning

confidence: 99%

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease

et al. 2017

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Painful vaso-occlusive crisis (VOC), a complication of sickle cell disease (SCD), occurs when sickled red blood cells obstruct flow in the microvasculature. We postulated that exaggerated sympathetically mediated vasoconstriction, endothelial dysfunction and the synergistic interaction between these two factors act together to reduce microvascular flow, promoting regional vaso-occlusions, setting the stage for VOC. We previously found that SCD subjects had stronger vasoconstriction response to pulses of heat-induced pain compared to controls but the relative degrees to which autonomic dysregulation, peripheral vascular dysfunction and their interaction are present in SCD remain unknown. In the present study, we employed a mathematical model to decompose the total vasoconstriction response to pain into: 1) the neurogenic component, 2) the vascular response to blood pressure, 3) respiratory coupling and 4) neurogenic-vascular interaction. The model allowed us to quantify the contribution of each component to the total vasoconstriction response. The most salient features of the components were extracted to represent biophysical markers of autonomic and vascular impairment in SCD and controls. These markers provide a means of phenotyping severity of disease in sickle-cell anemia that is based more on underlying physiology than on genotype. The marker of the vascular component (BMv) showed stronger contribution to vasoconstriction in SCD than controls (p = 0.0409), suggesting a dominant myogenic response in the SCD subjects as a consequence of endothelial dysfunction. The marker of neurogenic-vascular interaction (BMn-v) revealed that the interaction reinforced vasoconstriction in SCD but produced vasodilatory response in controls (p = 0.0167). This marked difference in BMn-v suggests that it is the most sensitive marker for quantifying combined alterations in autonomic and vascular function in SCD in response to heat-induced pain.

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“…(16) Although certain local factors such as temperature changes and tissue elasticity, can affect heart rate, the autonomic nervous system is the primary means by which the heart rate is controlled. (17) The Heart Rate Variability And Ans Activity…”

Section: Autonomic Nervous Systemmentioning

confidence: 99%

Analysis of heart rate variability in the measurement of the activity of the autonomic nervous system: technical note.

Brandão¹,

Sampaio²,

Brandão³

et al. 2014

mtprehabjournal

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Introduction: The analysis of heart rate variability (HRV) has been used as a resource for the measurement of autonomic nervous system activity in different situations. This analysis is based on identifying the strength of bands of low and high frequencies of the spectral function of the RR intervals in heart rate. Studies have shown that the related high frequency band parasympathetic tone controls the resting state, while exercise is associated with sympathetic activation, linked to lower frequency bands. The autonomic nervous system plays an important role in mediating the cardiovascular responses induced by stress. Objective: To describe a technique for analysis of heart rate variability in the measurement of autonomic nervous system activity. Discussion: To perform HRV analysis the "Nerve-Express" uses an effective and transparent visual representation, known as rhythmography method which reflects the structure of HRV wave and acts as a "fingerprint" of autonomic regulatory mechanisms. The wave RR intervals are recorded sequentially forming a rhythmogram, namely a picture of curved wave-specific variability of RR intervals. Key words: Heart Variability, Nerve-Express, Autonomic Nervous System, Salbutamol, doping. ResumoIntrodução: A análise da variabilidade da freqüência cardíaca tem sido empregada como recurso para a mensuração da atividade do sistema nervoso autônomo em diversas situações. Esta análise baseia-se na identificação da força das bandas de baixas e altas freqüências da função espectral dos intervalos R-R da freqüência cardíaca. Estudos revelaram que o tônus parassimpático relacionado à banda de alta freqüência controla o estado de repouso, enquanto o exercício está associado a uma ativação simpática, ligada às bandas de baixa freqüência. O sistema nervoso autônomo tem um papel importante na mediação das respostas cardiovasculares induzidas pelo estresse. Objetivo: Descrever a técnica de análise da variabilidade da frequência cardíaca na mensuração da atividade do sistema nervoso autônomo. Discussão: Para efetuar a análise da VFC, o "Nerve-Express" utiliza uma representação visual efetiva e transparente, conhecida como Método de Ritmografia, que reflete a estrutura de onda da VFC e atua como uma "impressão digital" dos mecanismos regulatórios autonômicos. Os intervalos de onda R-R são registrados sequencialmente, formando um ritmograma, ou seja, um retrato de onda curvo-específica da variabilidade dos intervalos R-R.

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The sympathetic nervous system's role in regulating blood pressure variability

Cited by 26 publications

References 60 publications

Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior

Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease

Analysis of heart rate variability in the measurement of the activity of the autonomic nervous system: technical note.

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