2013
DOI: 10.1007/s00520-013-1959-4
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The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study

Abstract: Symptom burden in patients with advanced NSCLC is high and has a negative impact on the quality of life. Patient-reported outcomes data could help optimize disease outcomes and therapy management in NSCLC.

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Cited by 201 publications
(162 citation statements)
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“…For example, brain or bone metastases or spread to liver or to the adrenal glands or spread to the intraabdominal lymph nodes are just some of the remoted manifestations of the disease that may coexist. Coughing can be a very distressing symptom (31). It can be present in more than 65% of patients with lung cancer.…”
Section: Symptomatologymentioning
confidence: 99%
“…For example, brain or bone metastases or spread to liver or to the adrenal glands or spread to the intraabdominal lymph nodes are just some of the remoted manifestations of the disease that may coexist. Coughing can be a very distressing symptom (31). It can be present in more than 65% of patients with lung cancer.…”
Section: Symptomatologymentioning
confidence: 99%
“…A few underlying causes have been mentioned, including nicotine use,191 physical discomfort such as dyspnoea and increased breathing effort,192 depression, and anxiety,193 seen in COPD194 as well as in NSCLC 195, 196…”
Section: Compromised Dietary Intakementioning
confidence: 99%
“…Basierend auf aktuellen Prävalenzangaben für die fortgeschrittene COPD (0,8 % im Alter ≥ 40 Jahre, GOLD Stadien III-IV [13]) oder den fortgeschrittenen Lungenkrebs (76 100, 5-Jahresprävalenz [27] ▶ Australien:50 % drei Monate vor Lebensende mit einem Anstieg auf 65 % in der letzten Lebenswoche [10]. In einer aktuellen multizentrischen Beobachtungsstudie über Patienten mit fortgeschrittenem Lungenkrebs in den USA (n = 450), Frankreich (n = 613) und Deutschland (n = 600) wurde jüngst eine besonders hohe Symptombelastung durch Atemnot (> 90 %) sowie ihr negativer Effekt auf die Lebensqualität dieser Patientengruppe beschrieben [18,19].…”
Section: Hintergrundunclassified