The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Serraj, Emanuel Andres Khalid

doi:10.4172/2155-9864.1000108

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…It should be emphasized that Carmel irst believed that FCM was associated with moderate cobalamin deiciency, leading to only "subtle" clinical symptoms ("subtle cobalamin deiciency") [30]. However in our experience, the clinical manifestations of FCM are not very diferent from those of cobalamin deiciencies associated with other causes, e.g., Biermer's disease [29].…”

Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 53%

“…As we have recently indicated, this syndrome is deined by cobalamin deiciency despite suicient cobalamin intake from food and a normal Schilling test, where the later rules out malabsorption or pernicious anemia [29]. FCM is caused primarily by atrophic gastritis [28].…”

Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 99%

“…FCM is caused primarily by atrophic gastritis [28]. Other factors that commonly contribute to FCM in elderly people include chronic carriage and infection of H. pylori; intestinal microbial proliferation; long-term ingestion of antacids (e.g., proton-pump inhibitors), and biguanides (metformin); chronic alcoholism; surgery or gastric reconstruction (e.g., bypass surgery for obesity); partial and pancreatic exocrine failure [29]. It should be emphasized that Carmel irst believed that FCM was associated with moderate cobalamin deiciency, leading to only "subtle" clinical symptoms ("subtle cobalamin deiciency") [30].…”

Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 99%

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Nutritional Anemia in Elderly Patients of Developed Countries

Andrès¹

2018

Current Topics in Anemia

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In this chapter, we report and discuss the current literature of nutrient-deiciency anemia, also called nutritional anemia, in elderly patients in developed countries. For this purpose, a review of medical literatures was conducted searching PubMed, textbooks of hematology, internal medicine and geriatrics, and information collected from international meetings were also included. The term nutrient deiciency or nutritional anemia covers any anemia, deined by a hemoglobin level <13 g/dL (<130 g/L) in men and <12 g/dL (<120 g/L) in women, resulting from a deiciency of materials essential for erythropoiesis. Patients with nutritional anemia often have mild to moderate anemia, with hemoglobin levels between 8 and 10 g/dL (80 and 100 g/L). In practice, nutritional anemia represents one-third of all anemia in elderly patients. About two-third of nutritional anemia is associated with iron deiciency and most of those cases are the result of chronic blood loss from gastrointestinal lesions. The remaining cases of nutritional anemia are usually associated with vitamin B12 (cobalamin), most frequently related to food-cobalamin malabsorption (especially in case of atrophic gastritis), and Biermer's disease (pernicious anemia); and/or vitamin B9 (folate) deiciency, most frequently related to inadequate dietary intake or malnutrition, several drugs (as methotrexate, cotrimoxazole) and chronic alcohol intake. In clinical practice, recognition of these disorders and deiciencies is essential for optimal treatment (nutrient-deiciency replacement).

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Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 53%

Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 99%

Section: Vitamin B9 and Vitamin B12 Deiciency Anemia In The Elderlymentioning

confidence: 99%

See 1 more Smart Citation

Nutritional Anemia in Elderly Patients of Developed Countries

Andrès¹

2018

Current Topics in Anemia

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Nutritional Anemia in Adults and in Elderly Patients

Andrès¹

2017

Management of Anemia

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Optimal management of pernicious anemia

Andrès¹,

Serraj²

2012

JBM

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Pernicious anemia (also known as Biermer’s disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%–50% of the causes of vitamin B12 deficiency in adults. Given its polymorphism and broad spectrum of clinical manifestations, pernicious anemia is a great pretender. Its diagnosis must therefore be evoked and considered in the presence of neurological and hematological manifestations of undetermined origin. Biologically, it is characterized by the presence of anti-intrinsic factor antibodies. Treatment is based on the administration of parenteral vitamin B12, although other routes of administration (eg, oral) are currently under study. In the present update, these various aspects are discussed with special emphasis on data of interest to the clinician.

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The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Cited by 8 publications

References 35 publications

Nutritional Anemia in Elderly Patients of Developed Countries

Nutritional Anemia in Elderly Patients of Developed Countries

Nutritional Anemia in Adults and in Elderly Patients

Optimal management of pernicious anemia

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