The synergic effect of the E298D polymorphism of the endothelial nitric oxide synthase gene and smoking status on the risk of cerebral stroke

Бушуева, О. Ю.; Stetskaya, Tatiana; Korogodina, T. V.; Иванов, В. П.; Polonikov, Alexey

doi:10.1134/s1022795415020052

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…In our study, we also revealed sex-specific correlates of HSPA8 genetic variants. Numerous proofs are presented in the literature that candidate genes for cardiovascular diseases are characterized by pronounced gender-specific effects in the manifestation of associations [ 62 , 63 , 64 , 65 , 66 ]. The association of rs10892958 with the development of IS in men found in our study is explained by the regulation of HSPA8 expression by sex hormones.…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that both of these risk factors are associated with high levels of reactive oxygen species [75,76] and, accordingly, oxidative stress, a major link contributing to the development of cardiovascular disorders [25,[77][78][79]. Smoking-specific correlates of candidate genes with risk of IS and stroke-related phenotypes have been demonstrated in many of our prior investigations [65,80], suggesting a significant role for smoking-induced endothelial dysfunction, vascular tone disorders, and atherosclerosis in the development of IS. The Comparative Toxigenomics Database offered proof of smoking's effects on the reduction of HSPA8 expression [81] as well as accelerating the metabolism of HSPA8 protein [82].…”

Section: Discussionmentioning

confidence: 99%

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Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Kobzeva

Soldatova

Stetskaya

et al. 2023

Genes

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HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07–1.77; p = 0.01) and patients with low fruit and vegetable consumption (OR = 1.36; 95% CI = 1.14–1.63; p = 0.002). SNP rs1136141 of HSPA8 was also associated with an increased risk of IS (risk allele A) exclusively in smokers (OR = 1.68; 95% CI = 1.23–2.28; p = 0.0007) and in patients with a low fruit and vegetable intake (OR = 1.29; 95% CI = 1.05–1.60; p = 0.04). Sex-stratified analysis revealed an association of rs10892958 HSPA8 with an increased risk of IS in males (risk allele G; OR = 1.30; 95% CI = 1.05–1.61; p = 0.01). Thus, SNPs rs10892958 and rs1136141 in the HSPA8 gene represent novel genetic markers of IS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Kobzeva

Soldatova

Stetskaya

et al. 2023

Genes

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“…The diseases caused by the rapid changes of the times are also called "modern civilization diseases". Phosphodiesterase 4D (PDE4D) can specifically degrade cAMP, and this effect may be related to coronary heart disease (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Wang studied the relationship between the phosphodiesterase 4D (PDE4D) gene single nucleic acid polymorphism and ischemic stroke and proved that the phosphodiesterase 4D (PDE4D) gene polymorphism can affect the cardiovascular and cerebrovascular (1). Bushueva used real-time PCR and TAPMN allelic discriminant analysis to perform phosphodiesterase 4D polymorphism genotyping in 230 coronary heart disease patients and 180 nearly healthy volunteers (2).…”

Section: Introductionmentioning

confidence: 99%

The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease

Yan

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Coronary atherosclerotic heart disease is one of the most common heart diseases that seriously endanger human health. The study found that intracellular second messenger CAMP plays an important role in inhibiting the proliferation and migration of vascular smooth muscle and the local inflammatory response at the damaged vessel. Phosphodiesterase 4D (PDE4D) can specifically degrade cAMP. The purpose of this article is to investigate the relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease and the effect of phosphodiesterase 4D gene polymorphism on cardiovascular, using polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) was used to detect 50 patients with coronary heart disease (ACS group) and 100 patients who were diagnosed with coronary artery disease by coronary angiography at the same time as the control group (NC group). The results of the study showed that the frequencies of AA, AG, and GG genotypes in 150 samples were 25.67%, 54.66%, and 22.67%, respectively, which was consistent with Hard Weber's law (X = 2.186, P = 0.101). The distribution of GG genotype (18% vs. 27%), AA + AG genotype (85% vs. 74%), G (57% vs. 55%), A (43% vs. 45 %) There was no statistically significant difference in allele frequency (P <0.05). From this, it can be seen that the rs918592 polymorphism of the PDE4D gene is not associated with coronary heart disease.

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“…Материалом для исследования послужила выборка неродственных, русских индивидов, проживающих в Курской области, общей численностью 852 человека. В исследование вошли 378 пациентов с МИ (217 мужчин, 161 женщина), которые находились на стационарном лечении в Региональном сосудистом центре Курской областной клинической больницы и в неврологическом отделении Курской Городской клинической больницы скорой медицинской помощи в период 2011-2017 гг [5][6][7]. Группу сравнения составили 474 практически здоровых добровольцев (263 мужчины, 211 женщин) без хронических заболеваний в анамнезе и имеющих нормальный уровень артериального давления.…”

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Роль Генов Антиоксидантной Системы В Формировании Предрасположенности К Развитию Цереброваскулярных Заболеваний: Анализ Ассоциаций Однонуклеотидных Полиморфизмов И Метилирования ДНК

Бушуева¹,

Барышева²,

Марков³

et al. 2021

Modern Issues of Biochemistry, Genetics and Biotechnology

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The synergic effect of the E298D polymorphism of the endothelial nitric oxide synthase gene and smoking status on the risk of cerebral stroke

Cited by 4 publications

References 38 publications

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease

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