The synergistic anti-inflammatory activities of agaro-oligosaccharides with different degrees of polymerization

Zou, Yaxue; Fu, Xiaoting; Liu, Nannan; Duan, Delin; Wang, Xueliang; Xu, Jiachao; Gao, Xin

doi:10.1007/s10811-019-1740-2

Cited by 29 publications

(18 citation statements)

References 36 publications

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“…However the more potent the biological effect, the higher the toxicity. Such an outcome has been reported in a similar study done by Zou et al (2019) whereby agaro-oligosaccharide fractions with the highest antiinflammatory activity also exhibited the highest cytotoxicity. The difference in toxicity and teratogenicity observed in OligoPKC when compared to MOS could be due to the oligosaccharide composition as well as structure.…”

Section: Discussionsupporting

confidence: 79%

“…Using a diaminoflourescein probe and a fluorescence microscope, the NO levels measured within the zebrafish larvae can be observed and measured as a response to stress and inflammation as demonstrated by Lepiller et al (2007) whereby the NO levels measured from induced injury or LPS stimulated zebrafish larvae were considerably higher than that of the control. This direct method of visualizing and quantifying an inflammatory response within a living vertebrate is fast gaining popularity as a rapid and relatively simple assay and this has subsequently led to several anti-inflammatory studies of natural products ( Lee, 2017 ; Gutierrez et al, 2018 ; Zou et al, 2019 ). Likewise, in this study, the optically transparent zebrafish larvae was utilized to observe the potential anti-inflammatory effects that NDOs have on zebrafish larvae when treated with lipopolysaccharide (LPS) from S. Enteritidis.…”

Section: Introductionmentioning

confidence: 99%

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Palm Kernel Cake Oligosaccharides Acute Toxicity and Effects on Nitric Oxide Levels Using a Zebrafish Larvae Model

et al. 2020

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Palm Kernel Cake Oligosaccharides Acute Toxicity and Effects on Nitric Oxide Levels Using a Zebrafish Larvae Model

et al. 2020

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“…The depletion of B. plebeius in severely diseased COVID-19 patients (0.58 as against 13.66 in healthy control participants) reflects a dampening of the immunoregulatory effects against inflammation and allergy [34,35]. The bacterium, characterized from the guts of Japanese natives, degrades seaweed porphyran and agarose into 3,6-Anhydro-L-galactose (AHG) and agaro-oligosaccharides [36,37], effecting an anti-inflammatory reaction through the inhibition of the MAPK and NF-κB pathways [38].…”

Section: Discussionmentioning

confidence: 99%

Gut Dysbiosis and IL-21 Response in Patients with Severe COVID-19

et al. 2021

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Background: The disease severity, ranging from being asymptomatic to having acute illness, and associated inflammatory responses has suggested that alterations in the gut microbiota may play a crucial role in the development of chronic disorders due to COVID-19 infection. This study describes gut microbiota dysbiosis in COVID-19 patients and its implications relating to the disease. Design: A cross sectional prospective study was performed on thirty RT-PCR-confirmed COVID-19 patients admitted to the All India Institute of Medical Sciences, Bhopal, India, between September 10 and 20, 2020. Ten healthy volunteers were recruited as the control group. IFN, TNF, and IL-21 profiling was conducted using plasma samples, and gut bacterial analysis was performed after obtaining the metagenomics data of stool samples. Results: Patients with a variable COVID-19 severity showed distinct gut microflora and peripheral interleukin-21 levels. A low Firmicute/Bacteroidetes ratio, caused by the depletion of the fibre-utilizing bacteria, F. prausnitzii, B. Plebius, and Prevotella, and an increase in Bacteroidetes has associated gut microbiota dysbiosis with COVID-19 disease severity. Conclusions: The loss of the functional attributes of signature commensals in the gut, due to dysbiosis, is a predisposing factor of COVID-19 pathophysiology.

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“…Intracellular cell death, ROS, and NO in zebrafish embryos were estimated according to the method by Zou et al [ 68 ].…”

Section: Methodsmentioning

confidence: 99%

Molecular Mechanism of Anti-Inflammatory Activities of a Novel Sulfated Galactofucan from Saccharina japonica

Chen

et al. 2021

Marine Drugs

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Seaweed of Saccharina japonica is the most abundantly cultured brown seaweed in the world, and has been consumed in the food industry due to its nutrition and the unique properties of its polysaccharides. In this study, fucoidan (LJNF3), purified from S. japonica, was found to be a novel sulfated galactofucan, with the monosaccharide of only fucose and galactose in a ratio of 79.22:20.78, and with an 11.36% content of sulfate groups. NMR spectroscopy showed that LJNF3 consists of (1→3)-α-l-fucopyranosyl-4-SO3 residues and (1→6)-β-d-galactopyranose units. The molecular mechanism of the anti-inflammatory effect in RAW264.7 demonstrated that LJNF3 reduced the production of nitric oxide (NO), and down-regulated the expression of MAPK (including p38, ENK and JNK) and NF-κB (including p65 and IKKα/IKKβ) signaling pathways. In a zebrafish experiment assay, LJNF3 showed a significantly protective effect, by reducing the cell death rate, inhibiting NO to 59.43%, and decreasing about 40% of reactive oxygen species. This study indicated that LJNF3, which only consisted of fucose and galactose, had the potential to be developed in the biomedical, food and cosmetic industries.

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The synergistic anti-inflammatory activities of agaro-oligosaccharides with different degrees of polymerization

Cited by 29 publications

References 36 publications

Palm Kernel Cake Oligosaccharides Acute Toxicity and Effects on Nitric Oxide Levels Using a Zebrafish Larvae Model

Palm Kernel Cake Oligosaccharides Acute Toxicity and Effects on Nitric Oxide Levels Using a Zebrafish Larvae Model

Gut Dysbiosis and IL-21 Response in Patients with Severe COVID-19

Molecular Mechanism of Anti-Inflammatory Activities of a Novel Sulfated Galactofucan from Saccharina japonica

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