The synergistic cooperation between MCM-41 and azithromycin: a pH responsive system for drug adsorption and release

Hamzehloo, Majid; Karimi, Jahangir; Aghapoor, Kioumars; Sayahi, Hani; Darabi, Hossein Reza

doi:10.1007/s10934-017-0538-3

Cited by 17 publications

(6 citation statements)

References 53 publications

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“…Clearly, the pH of the solution greatly influenced the adsorption process of macrolide antibiotics, and the uptake of AZM and ROX was increased from 0.67 mg/g to 36.69 mg/g and 16.59 mg/g to 49.04 mg/g, respectively, when pH increased from 3.0 to 13.0. This situation was consistent with the conclusions of a previous study [35]. As a result, the adsorption capacity of 6 h-synthesized zeolite EMANA is low at low pH values, specifically below 5, due to electrostatic repulsion between macrolide antibiotics and 6 h-synthesized zeolite EMANA.…”

Section: Resultssupporting

confidence: 93%

Synthesis of Zeolite from Carbothermal Reduction Electrolytic Manganese Residue for the Removal of Macrolide Antibiotics from Aqueous Solution

Zeng

Chen

et al. 2018

Materials

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Zeolite analcime (EMANA) was synthesized through the hydrothermal method by using carbothermal reduction electrolytic manganese residue (CR-EMR). The structural properties of EMANA and CR-EMR were studied using various characterization techniques. After hydrothermal synthesis, the CR-EMR became super-microporous, and the surface area increased by 4.76 times than before. Among the various synthesized zeolites, 6 h-synthesized EMANA was selected as the best adsorbent for macrolide antibiotics in aqueous solution. The adsorption performance of EMANA on the adsorption capacity was examined by using various experimental parameters, such as contact time (0–24 h), initial concentration (50–300 mg/L), temperature (30–50 °C) and pH (3–13). The experimental results were also analyzed by the Langmuir and Freundlich adsorption models, with the latter obtaining better representation. The adsorption process could be described well by the pseudo-second-order model, even under a low concentration (50 mg/L). This result suggests that the adsorption process of macrolide antibiotics is due to chemisorption. According to the Fourier Transform infrared spectroscopy (FT-IR) results, the adsorption of zeolite was mainly due to its hydroxyl group, which played an important role during the adsorption process. Moreover, EMANA is more suitable for treatment of roxithromycin (ROX) than azithromycin (AZM), because ROX has more adsorption sites for the hydroxyl group.

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Section: Resultssupporting

confidence: 93%

Synthesis of Zeolite from Carbothermal Reduction Electrolytic Manganese Residue for the Removal of Macrolide Antibiotics from Aqueous Solution

Zeng

Chen

et al. 2018

Materials

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“…The mechanism of 5-FU in-vitro release from SBA-15_N-ANI_5-FU_β-CD system was also studied from a kinetic point of view. In general, the release kinetics of drugs from ordered mesoporous materials mainly follows First order model or Higuchi one [54][55][56][57]. While the First Order model is general, the Higuchi one can be used for the description of drug release from spherical systems and various geometric porous matrices [58].…”

Section: Kinetics Of Drug Releasementioning

confidence: 99%

Adsorption properties, the pH-sensitive release of 5-fluorouracil and cytotoxicity studies of mesoporous silica drug delivery matrix

Beňová

Bergé‐Lefranc

Zeleňák

et al. 2020

Applied Surface Science

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Mesoporous silica materials were investigated as the carriers for pH-sensitive drug delivery systems. Porous silica SBA-15 was first functionalized by anchoring N-[3-(trimethoxysilyl) propyl] aniline groups on the surface. After loading of an antineoplastic agent 5-fluorouracil, the pores were capped by β-cyclodextrin molecules. The studied samples were characterized by N 2 adsorption/desorption measurements, thermal analysis, powder X-Ray Diffraction, and Transmission Electron Microscopy. Adsorption properties of 5-fluorouracil were explored via the construction of adsorption isotherms. The amount of 5-FU adsorbed on amine-functionalized SBA-15 was 60 mg per 1 g of solid. The adsorption of 5-fluorouracil on silica was also monitored by microcalorimetry, showing low adsorption enthalpies. Drug release properties from matrices were studied using UV-Visible spectroscopy with the un-blocked and blocked pores configuration to demonstrate the efficiency of the pH-responsive nanovalves and evaluated using different kinetic models. It was shown that no drug release occurred at neutral pH and that more than 80% of drug adsorbed amount was released at pH = 5. Working at the equilibrium, the initial burst of the drug from the silica surface, usually observed in other porous silica drug delivery systems, was avoided. The interaction between the β-cyclodextrin molecules and grafted amine functions were also studied as a function of pH. Finally, the cytotoxicity tests were performed using human glioma U87 MG cells.

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“…Among the developed nano-carriers, mesoporous silica nanoparticles (MSN) [17][18][19][20][21][22][23][24][25][26][27][28] have shown great potential for applications in drug delivery vehicles due to its biocompatibility, high surface area, and tendency to undergo cellular uptake into acidic lysosomes by endocytosis when having a diameter of 100-200 nm. Consequently, several drug delivery systems based on MSNs have been developed during the last decade [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. In these systems, controlled release of drug can be achieved in response to various stimuli such as light, redox potential, temperature, pH and enzymes.…”

Section: Introductionmentioning

confidence: 99%

“…Various pH responsive MSN have been developed using different capping agents, such as polymer, biomolecules and also inorganic nanoparticles [37,38,[43][44][45][46][47][48][49][50] The challenge here is to find the responsive capping agent that can effectively release the drug selectively on the cancer cells.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive porphyrin-silica nanoparticles conjugate via ionic self-assembly

Fathalla

Sinatra

2020

J Porous Mater

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Ionic self-assembly (ISA) is a powerful tool that has been exploited to create various functional nanomaterials through the electrostatic interactions of different building blocks. Herein, we disclose for the first time the synthesis and characterization of benzoic acid functionalized silica nanoparticles (MSN-Bn) and its subsequent ISA with meso-tetrakis(N-methylpyridinium-4yl)porphyrin (TMPyP) to form a pH responsive hybrid material. The resulting pH responsive conjugate is an attractive candidate as a drug delivery vehicle in which the MSN-Bn act as a drug carrier and the TMPyP act as a capping agent for the silica nanopores. The application of these pH-responsive interactions between the negatively charged carboxylate groups on the surface of mesoporous silica nanoparticles and the positively charged porphyrin as a drug delivery system was investigated by studying the loading and release of Hoechst 33342 dye (a water-soluble biological stain with similar size to those of therapeutic drugs) in response to a pH change. The reported approach enables the delivery of a chemotherapeutic drug in addition to the TMPyP, which is also well-known as a photodynamic therapy (PDT) agent, thus paving the way for synergistic chemo-photodynamic cancer therapy. The study shows that the resulting conjugate demonstrate the drug delivery mechanism which is responsive to changing the pH values from 7.5 to 4.5, and can deliver about 2wt% of the chemotherapeutic drug tested.

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The synergistic cooperation between MCM-41 and azithromycin: a pH responsive system for drug adsorption and release

Cited by 17 publications

References 53 publications

Synthesis of Zeolite from Carbothermal Reduction Electrolytic Manganese Residue for the Removal of Macrolide Antibiotics from Aqueous Solution

Synthesis of Zeolite from Carbothermal Reduction Electrolytic Manganese Residue for the Removal of Macrolide Antibiotics from Aqueous Solution

Adsorption properties, the pH-sensitive release of 5-fluorouracil and cytotoxicity studies of mesoporous silica drug delivery matrix

pH-Responsive porphyrin-silica nanoparticles conjugate via ionic self-assembly

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