The synergistic effect of tranexamic acid and ethamsylate combination on blood loss in pediatric cardiac surgery

Abstract

Background: Pediatric patients are at risk for bleeding after cardiac surgery. Administration of antifibrinolytic agents reduces postoperative blood loss. Objective: Evaluation of the efficacy of combined administration of tranexamic acid (TXA) and ethamsylate in the reduction of postoperative blood loss in pediatric cardiac surgery. Methods: This prospective randomized study included 126 children submitted for cardiac surgery, and they were allocated into three groups: control group ( n = 42); TXA group ( n = 42):- received only TXA; and combined ethamsylate TXA group ( n = 42):- received a combination of TXA and ethamsylate. The main collected data included sternal closure time, the needs for intraoperative transfusion of blood and its products, the total amount of blood loss, and the amount of the whole blood and its products transfused to the patients in the first 24 postoperative hours. Results: Blood loss volume in the first 24 postoperative hours was significantly smaller in combined group than the TXA and control groups and was significantly smaller in the TXA group than the control group. The sternal closure time was significantly shorter in the combined group than the other 2 groups and significantly shorter in TXA than the control group. The amount of whole blood transfused to patients in the combined group during surgery and in the first postoperative 24 h was significantly smaller than the other 2 groups and smaller in TXA group than the control group during surgery. Conclusion: Combined administration of ethamsylate and TXA in pediatric cardiac surgery was more effective in reducing postoperative blood loss and whole blood transfusion requirements than the administration of TXA alone.

Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy

“…While oxytocin increases muscular uterine contractility and thus reduces bleeding [ 34 ]. Both tranexamic acid and ethamsylate are cost-effective drugs and give a synergistic impact than tranexamic acid alone [ 18 , 35 ]. A previous randomized control trial showed that the tranexamic acid and ethamsylate combination had a synergetic effect on decreasing post-operative bleeding when administrated in pediatric cardiac surgery [ 35 ].…”

Perioperative oxytocin infusion versus tranexamic acid and ethamsylate in reducing intraoperative blood loss during caesarean section: a systematic review and meta-analysis

“…Eth and TXA exhibit a synergistic effect in hemostasis when administered intravenously together. This combined approach proves effectively minimizes intra-and postoperative blood loss [12].…”

“…TXA and ethamsylate (TXAEth) complement each other in hemostasis. Administering both intravenously could synergistically reduce intra-and postoperative blood loss [12]. The comparative effectiveness between oxytocin alone and the combined use of TXA and Eth remains unclear.…”

Tranexamic Acid Versus Etamsylate in Reducing Blood Loss During Normal Vaginal Delivery in Patients with High Risk of Postpartum Hemorrhage: Randomized Controlled Trial

“…TXA is most frequently used in the treatment of idiopathic menorrhagia and pregnancy-related bleeding (threatened abortion and placenta previa) in obstetric and gynecologic therapy (24) .…”