The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial

Parohan, Mohammad; Sarraf, Payam; Javanbakht, Mohammad Hassan; Foroushani, Abbas Rahimi; Ranji-Burachaloo, Sakineh; Djalali, Mahmoud

doi:10.1080/1028415x.2019.1627770

Cited by 51 publications

(47 citation statements)

References 45 publications

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“…Reductions in the number of headache episodes, moderate or severe headaches, and migraine days by approximately 3 per month with NEC are clinically meaningful improvements and equivalent to the results of migraine prophylaxis trials with anti‐CGRP antibodies, 4–9,56 beta blockers, 57,58 topiramate, 59–62 botulinum toxin, 63,64 and nutraceuticals such as curcumin and coenzyme Q, 39,40 riboflavin, 66–68 and melatonin 69 . There were also decreases in all outcome measures in the sham treatment group consistent with the strong placebo effect reported in many migraine trials 70 .…”

Section: Discussionsupporting

confidence: 62%

“…Research has established that these processes, and in particular the generation of NO in the brain, plays a major role in migraine 17–25 . Limited data from clinical trials suggest that antioxidants such as Vit C and Vit E may improve migraine outcomes; however, further studies are required 39–43 . Our study adds to the body of clinical evidence that antioxidants might have a preventive effect in migraine.…”

Section: Discussionmentioning

confidence: 82%

“…There have only been 5 small clinical studies of antioxidants in the treatment of migraine. Two randomized controlled trials (RCTs) found the antioxidants curcumin and coenzyme Q10 decreased migraine frequency 39,40 and a single RCT reported that Vit E decreased menstrual migraines 41 . Finally, 2 uncontrolled studies reported a decrease in migraine symptoms with an antioxidant combination of pine bark extract, Vit C, and Vit E 42,43 …”

Section: Introductionmentioning

confidence: 99%

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Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

2020

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Objective To investigate the preventive effects of a combined antioxidant drug (N‐acetylcysteine, vitamin E, and vitamin C [NEC]) on migraine outcomes. Migraine is characterized by increased oxidative stress and neurogenic inflammation in the brain; therefore, antioxidants may have a migraine preventive effect. Design Randomized, double‐blind, sham‐controlled pilot study. Setting Australian community. Subjects Adults reporting 2 to 8 migraines per month for at least a year. Methods After a 1‐month baseline period, 35 subjects completed 3 months of treatment with NEC (n = 19) or sham (n = 16) capsules. The primary outcome was the difference in mean number of headaches per month between baseline and final month of the trial for NEC and sham groups; secondary outcomes are listed below. Results For NEC there was a significant decrease in mean number of headaches by 3.0 per month (P = 0.004) compared with 1.4 for sham (P = 0.073); there was no significant difference in these changes between the 2 groups (P = 0.052). Average monthly headache (P = 0.041) and migraine frequency (P = 0.018) were significantly less for NEC vs. sham. In NEC subjects, there was a significant decrease in average monthly migraine days (−3.1), moderate/severe headache days (−3.2), migraine duration, headache pain scores, and acute headache medication use. Conclusions This is the first randomized controlled trial to find that combined antioxidant therapy with NEC reduces headaches and migraines in adult migraineurs. Given the limitations of this pilot study, an adequately powered randomized controlled trial is planned to further investigate antioxidant prophylaxis in migraine.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

2020

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“…In particular, Gaul and collaborators observed on 173 adults affected by migraine that a fixed combination of magnesium (600 mg/day), riboflavin (400 mg/day), and CoQ 10 (150 mg/day) after 3 months of treatment reduced migraine pain without any serious adverse events [158]. Moreover, preliminary but encouraging results in the prophylaxis of migraine have been observed in a recent RCT, where the assumption of soft gelatin capsules containing nano-micellar curcumin (80 mg/day) and CoQ 10 (300 mg/day) determined a significant reduction of frequency, severity, and duration of migraine attacks (all p < 0.001) [159].…”

Section: Migrainementioning

confidence: 88%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ10 is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ10 supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ10 supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

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“…The results of this study show that joint administration of curcumin and coenzyme Q10 has a positive effect on decreasing the frequency of migraine attacks, their duration, and severity of symptoms. Additionally, the patients did not report side effects with respect to the antioxidants used in the study [70] (Table 2).…”

Section: Curcuminmentioning

confidence: 99%

The Use of Antioxidants in the Treatment of Migraine

et al. 2020

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Despite numerous studies concerning the pathophysiology of migraine, the exact molecular mechanism of disturbances underlying migraine is still unknown. Furthermore, oxidative stress is considered to play a significant role in migraine pathogenesis. The notion of oxidative stress in migraine patients has been discussed for several decades. Over the past few years, among the substances that could potentially be used for migraine treatment, particular attention has been paid to the so-called nutraceutics, including antioxidants. Antioxidants supplied with food prevent oxidative stress by inhibiting initiation, propagation, and the oxidative chain reaction itself. Additionally, the agents used so far in the prevention of migraine indeed show some anti-oxidative action. The antioxidants discussed in the present paper are increasingly more often used by migraine patients not only due to mild or even a lack of side effects but also because of their effectiveness (decreased frequency of migraine episodes or shortening of an episode duration). The present review provides a summary of the studies on nutraceuticals with antioxidative properties.

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The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial

Cited by 51 publications

References 45 publications

Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N‐acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham‐Controlled Pilot Study

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

The Use of Antioxidants in the Treatment of Migraine

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