The synthesis and antimicrobial activity of some new methyl N-arylthiocarbamates, dimethyl N-aryldithiocarbonimidates and 2-arylamino-2-imidazolines

Servi, Süleyman; Genç, Murat; Gür, Seyfettin; Koca, Murat

doi:10.1016/j.ejmech.2005.02.002

Cited by 37 publications

(10 citation statements)

References 13 publications

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“…Substituted thiadiazole derivatives have been found to show diverse pharmacological activities such as analgesic (Schenone et al, 2006), antidepressant and anxiolytic (Clerici and Pocar, 2001), anticonvulsant Chapleo et al, 1986), anti-inflammatory (Mullican et al, 1993), antimicrobial (Servi et al, 2005), antitubercular (Oruç et al, 2004), antitumor (Matysiak, 2006) and antiviral (Jones et al, 1965) activity. A series of 2-amino-5-sulfanyl-1,3,4-thiadiazoles originally been synthesized and evaluated for antidepressant and anxiolytic activity by Clerici and Pocar (2001).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

et al. 2010

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“…These 1,3,4-thiadiazole compounds are associated with diverse pharmacological activities such as analgesic (Schenone et al, 2006), antidepressant and anxiolytic (Clerici and Pocar, 2001), anticonvulsant (Chapleo et al, 1986;Stillings et al, 1986), anti-inflamatory (Mullican et al, 1993), antimicrobial (Servi et al, 2005;Foroumadia et al, 2005), antitubercular (Oruç et al, 2004), antitumor (Matysiak, 2006), and antiviral (Jones et al, 1965) activity. A series of 2-amino-5-sulfanyl-1,3,4-thiadiazoles exemplified by the general structure in Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazoles as antidepressant, anxiolytic, and anticonvulsant agents

Pattanayak¹,

Sharma

Sahoo³

2008

Med Chem Res

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The purpose of this study was to evaluate the title compounds on central nervous system activity by varying the substituents in the thiadiazole moiety. The newly synthesized intermediates and compounds were characterized by spectral analysis. Two of the tested compounds (3a and 3b) exhibited excellent antidepressant, anxiolytic, and anticonvulsant activity in comparison with the reference drugs.Keywords Tail suspension test Á Forced swim test Á Elevated plus maze Á Light and dark box Á Maximal electroshock test Á PTZ animal model

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“…THSG is one of the stilbene derivatives which are distributed abundantly in plants and have a number of interesting biological activities [7,8]. Although THSG is similar to other stilbene derivatives in their chemical structures, their effects on tyrosinase activity differ greatly.…”

Section: Discussionmentioning

confidence: 99%

Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis

Guan

Sui

Wang

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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Radix Polygoni multiflori is a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine but its active ingredients have not been discovered yet. In this investigation, we tested six compounds isolated from Radix Polygoni multiflori, to discover the active component on melanogenesis. Three experiments were performed in the present investigation: mushroom tyrosinase activity, melanin content B16 cell proliferation assay. Among all the six components tested, THSG showed the most potent effects on tyrosinase activation and melanogenesis; it was shown to be a potent tyrosinase activator and a melanogenesis stimulator in this study. On the other hand, we found that gallic acid significantly inhibited tyrosinase and, in addition, anthraquinones were cytotoxic to melanoma cells. They were both harmful to melanogenesis. Therefore, we propose that THSG acts as the active ingredient of Radix Polygoni multiflori on melanogenesis.

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The synthesis and antimicrobial activity of some new methyl N-arylthiocarbamates, dimethyl N-aryldithiocarbonimidates and 2-arylamino-2-imidazolines

Cited by 37 publications

References 13 publications

Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

Synthesis and evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazoles as antidepressant, anxiolytic, and anticonvulsant agents

Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis

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