The synthesis and crystal structure of imidazolate-bridged [Cu(tern)(im)Zn(tren)](ClO₄)₃·MeOH (tren = tris(2-aminoethyl)amine; im = imidazolate]

Abstract

The reaction of [ C ~( t r e n ) ] ( C l O ~) ~ [tren = tris(2-aminoethyl)amine] with [Zn(tren)](C104)2 and imidazole in alkaline MeOH-H20 solution gives imidazolate-bridged [C~(tren)(im)Zn(tren)](CIO~)~-MeOH (im = imidazolate) which is similar to the active centre of superoxide dismutase as shown by X-ray crystallography.

Development of novel copper(II) complexes of benzothiazole-N-sulfonamides as protective agents against superoxide anion. Crystal structures of [Cu(N–2-(4-methylbenzothiazole)benzenesulfonamidate)2(py)2] and [Cu(N–2-(6-nitrobenzothiazole)naphthalenesulfonamidate)2(py)2]

“…Data for compound N-2-(4-methylbenzothiazole)benzenesulfonamide (HL1) (yield 68%). C 14 [Cu(L2) 2 (py) 2 ] (2). This compound was obtained by using a procedure similar to that described for complex 1.…”

“…In contrast, the stable, non-toxic metal complexes which catalyze the dismutation of superoxide anion show considerable promise as SOD mimics for pharmaceutical application and have attracted much attention [7]. Although many SOD mimics, including copper(II) complexes of polypeptides [8,9], polydentate Schiff bases [10,11], mixed ligands [12,13], and imidazolate-bridged heterobinuclear Cu-Zn complexes [14,15] or binuclear copper complexes [16,17] have been reported, only a few are highly active in the range of physiological pH. Some factors have been proposed which may discriminate among the dismutation abilities of the copper complexes and these may include:…”

Synthesis, structure and biomimetic properties of Cu(II)–Cu(II) and Cu(II)–Zn(II) binuclear complexes: possible models for the chemistry of Cu–Zn superoxide dismutase

“…At the next step, another O À 2 anion approaches and oxidizes Cu(I) to Cu(II) and O À 2 is reduced to HO À 2 which is further protonated by water to give On the other hand, the Zn(II) center primarily plays a supportive role and it indirectly helps the formation and stablisation of the active Cu-site in the course of reaction. Imidazolate bridged heterobinuclear Cu II Zn II complexes are still very rare to date [4][5][6][7][8][9]. Therefore, in the course of our studies on synthetic dinuclear transitionmetal complexes [10][11][12][13][14][15][16][17][18][19][20], we have synthesized and characterized four dinuclear complexes viz., [(Bipy) 2-Cu-Im-Cu(Bipy) 2 ](ClO 4 ) 3 AE CH 3 OH, [(Phen) 2 Cu-ImCu(Phen) 2 ](BF 4 ) 3 AE 2CH 3 OH, [(Bipy) 2 Cu-Im-Zn (Bipy) 2 ] (BF 4 ) 3 and [(Phen) 2 Cu-Im-Zn(Phen) 2 ](BF 4 ) 3 .…”

Strong protective action of Copper(II) N-substituted sulfonamide complexes against reactive oxygen species

“…Because copper is a cofactor in the active site of native SOD, low molecular weight chelates of copper can be used as mimics of Cu 2 Zn 2 SOD. For many years efforts have been made to obtain model compounds that show catalytic properties similar to that of the active site of Cu 2 Zn 2 SOD [6][7][8][9][10][11][12][13][14][15][16].…”