The synthesis and functionalization of metal organic frameworks and their applications for the selective separation of proteins/peptides

Wang, Jundong; Hu, Tingxia; Han, Qiang; Luo, Wen; Zhong, Jingming; Ding, Mingyu

doi:10.1007/s00216-023-04843-z

Anal Bioanal Chem

2023

DOI: 10.1007/s00216-023-04843-z

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The synthesis and functionalization of metal organic frameworks and their applications for the selective separation of proteins/peptides

Jundong Wang

Tingxia Hu

Qiang Han

et al.

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2024

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Cited by 4 publications

References 89 publications

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Boronic Acid‐Rich Lanthanide Metal‐Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples

Zhang,

Ghalandari,

Chen

et al. 2024

Advanced Materials

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Label‐free proteomics is widely used to identify disease mechanism and potential therapeutic targets. However, deep proteomics with ultratrace clinical specimen remains a major technical challenge due to extensive contact loss during complex sample pretreatment. Here, a hybrid of four boronic acid‐rich lanthanide metal‐organic frameworks (MOFs) with high protein affinity is introduced to capture proteins in ultratrace samples jointly by nitrogen‐boronate complexation, cation‐π and ionic interactions. A MOFs Aided Sample Preparation (MASP) workflow that shrinks sample volume and integrates lysis, protein capture, protein digestion and peptide collection steps into a single PCR tube to minimize sample loss caused by non‐specific absorption, is proposed further. MASP is validated to quantify ≈1800 proteins in 10 HEK‐293T cells. MASP is applied to profile cerebrospinal fluid (CSF) proteome from cerebral stroke and brain damaged patients, and identified ≈3700 proteins in 1 µL CSF. MASP is further demonstrated to detect ≈9600 proteins in as few as 50 µg mouse brain tissues. MASP thus enables deep, scalable, and reproducible proteome on precious clinical samples with low abundant proteins.

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Boronic Acid‐Rich Lanthanide Metal‐Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples

Zhang,

Ghalandari,

Chen

et al. 2024

Advanced Materials

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MOFs functionalization of 3D printed mullite complex architectures for CO2 capture

Bertero,

Schmitt,

Kaper

et al. 2024

Applied Materials Today

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Applications of luminescent metal-organic frameworks as pioneering biosensors for biological and chemical detection

Fang,

Wang,

Ding

2024

Chinese Chemical Letters

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The synthesis and functionalization of metal organic frameworks and their applications for the selective separation of proteins/peptides

Cited by 4 publications

References 89 publications

Boronic Acid‐Rich Lanthanide Metal‐Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples

Boronic Acid‐Rich Lanthanide Metal‐Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples

MOFs functionalization of 3D printed mullite complex architectures for CO2 capture

Applications of luminescent metal-organic frameworks as pioneering biosensors for biological and chemical detection

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