The Synthesis and Human FP Receptor Binding Affinity of 13,14-Dihydro Prostaglandin F1.ALPHA. Sulfonamides. Potential Treatments for Osteoporosis.

H3PW12O40-SoiO2and Amberlyst 15: Two Efficient Heterogeneous Catalysts for Synthesis of N-Acylsulfonamides under Solvent-free Conditions

“…9 However, most of these procedures have signicant drawbacks such as long reaction times, low yields, harsh reaction conditions, tedious workup procedures, or use of environmentally toxic reagents or media. Thus, there is still need of a simple and general procedure for the N-acylation of sulfonamides under mild conditions.…”

N-Sulfonylation of amines, imides, amides and anilides using p-TsCl in presence of atomized sodium in EtOH–THF under sonic condition

“…Since under mild conditions sulfonamides can be recovered easily from the reaction mixture they are used as protecting groups for the ANHA functionality [11]. Several drugs including therapeutic agents for Alzheimer's disease [12], inhibitors of tRNA synthetases, antibacterial agents [13], prostaglandin F1a sulfonamides for the potential treatment of osteoporosis [14], antagonists for angiotensin II [15], and leukotriene D4-receptors [16] possess the N-sulfonyl moiety. Protocols documented in the literature for the N-sulfonylation involves use of metal oxides (MgO, Ag 2 O, CuO, ZnO), Zn-Al hydrotalcite, CsFCelite as catalysts and N-chlorosulfonyl carbamate (CSC) [17].…”

P2O5/SiO2 as an efficient and recyclable catalyst for N-Acylation of sulfonamides under heterogeneous and solvent-free conditions

“…The most practical methods for the N-acylation of sulfonamides are the reaction of parent sulfonamide with acyl chlorides or anhydrides using trialkylamines and pyridine [5] or alternatively with alkali hydroxides [6]. Another approach utilizes carboxylic acids along with condensing agents such as carbodiimides (EDC, DCC) and N,N'-carbonyl diimidazole [2,7]. Recently, Katrizky et al reported N-acylation of sulfonamides using Nacyl benzotriazole as the acylating agent [8].…”

“…However, most of these methods have some disadvantages including occurrence *Corresponding author. E-mail: Massah@iaush.ac.ir of side reactions especially formation of biacylated byproducts [5,] vigorous reaction conditions and tedious work-up [10], use of expensive or unavailable reagents and solvents [7,8], long reaction times and low yield of products [7]. Thus, there is still demand for developing new and mild methods for N-acylation of sulfonamides in the presence of inexpensive and bench top reagents.…”