The synthesis and reactivity of ferrocenyloxy)-2-tetrahydropyran

Synthesis and biological evaluations of some Schiff-base esters of ferrocenyl aniline and simple aniline

“…In last few years organometallics have got great importance owing to their potential biological activities [3,4]. Among organometallics, ferrocene is known as chemically and thermally stable specie.…”

“…Nowadays, ferrocene is no longer a chemical curiosity, rather it provides a widely applicable platform for the preparation of functional derivatives used in many areas like catalysis, material science, crystal engineering and bio-organometallic chemistry [5][6][7][8]. The activities of certain drugs are reported to be enhanced by the addition of ferrocene moiety to their structures; e.g., ferrocene aspirin [4], antimalarial drug ferrocene quine [9], an anticancer drug ferrocifen [10], ferrocene-hydroxytamoxifen [11] and ferrchloroquine [12]. The anticancer potential of ferrocene containing compounds is also well reported [13][14][15][16].…”

Synthesis of novel ferrocene containing vic-dioxime ligands and their Ni(II), Cu(II) and Co(II) complexes: Spectral, electrochemical and biological activity studies

“…The new vic-dioxime ligands (1a, 1b) were subjected to elemental analyses, FT-IR, UVevis, MS and NMR ( 1 H NMR, 13 C NMR and HMBC) spectral studies. Our analyses of 1a and 1b agree with the suggested structures.…”

“…[12]. The activities of certain drugs are reported to be enhanced by the addition of ferrocene moiety to their structures; e.g., ferrocene aspirin [13], the antimalarial drug ferrocene quinine [14], and anticancer drug ferrocifen [15]. The anticancer potential of ferrocene-containing compounds is also well reported [16e18].…”

Synthesis, characterization, and biological evaluation of novel ferrocene-triadimefon analogues

“…The stability, non-toxicity and readily membrane-permeation of the ferrocenyl group, the accessibility of a large variety of derivatives, as well as its favorable electrochemical properties have made ferrocene and its derivatives very suitable for biological applications and for conjugation with biomolecules [11]. Several structural modification of established drugs with ferrocenyl moiety have been reported, such as ferrocene fluconazole [12], ferrocene aspirin [13], the anti-malarial drugs chloroquine (termed ferroquine), quinine, mefloquine, and artemisinin [14], and the anti-cancer drug tamixofen (termed ferrocifen) [15].…”