The synthesis and the antimicrobial activity of the substituted aryl amides of 3-arylmethyl-2,4- dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylic acids

Abstract

[5], and the purulent inflammatory diseases the development of the novel antibacterial drugs is an important approach to treat and control infections. It is known that derivatives of 3-arylmethyl-1,3,7-triazospiro[4.4]nonane-2,4-dione (compounds of the general formula 1) and their Nbenzoyl derivatives exhibit the moderate antimicrobial activity against the strains of gram-positive and gramnegative bacteria, as well as against fungi [3]. Therefore, the aim of our work was to develop the novel antimicrobial substances with the similar structure from aryl amides of the series of 3-arylmethyl-2,4-dioxo-1,3,7-triazospiro[4.4]nonane-7-carboxylic acids. Experimental Part Chemical PartAll solvents and reagents were obtained from the commercial sources. The NMR-spectra were recorded with a Bruker 170 Avance 500 spectrometer at 500 МHz for NMR 1 Н-spectra and at 125 МHz for NMR 13 С-spectra, the solvent was DMSO-d 6 ; TMS was used as an internal standard. Chromato-mass spectra were recorded using an Agilent 1100 HPLC device equipped with a diode matrix detector and a mass-spectrometer (Agilent LC-MSD SL); a Zorbax SB-C18 column (4.6×15 mm) and an atmospheric pressure chemical ionization (APCI) were used for the analyses. The TLC was performed on the alu-