The synthesis, characterization and antibacterial activities of dinuclear Ni(II), Cu(II) and Fe(III) Schiff base complexes

Abstract

Schiff base; N,N' bis (2 hydroxy 1 naphthaldimine) 1,3 diaminopropanol (napdapOH) reacts with metal chlorides to form dinuclear complexes of the type [M 2 L 2 ] ⋅ nCl 2 where M = Ni, Cu, Fe and n = 0, 1. Schiff base complexes were characterized by using FT IR, LC MS, magnetic moments and conductance measurements. Coordination was found to be through the phenolic oxygen atoms and azomethine nitrogen atoms. The electronic properties of the compounds were investigated theoretically by performing semi empirical molecular orbital theory PM3 method in Hyperchem 7 (Release). The antibacterial activities of the compounds were investigated against Escherichia coli ATCC 11230, Bacillus subtilis RSKK 244, Bacillus megaterium RSKK 5117, Salmonella enteritidis ATCC 13076, Staphylococcus aureus ATCC 25923 by using microdilution method.

Template synthesis, DNA binding, antimicrobial activity, Hirshfeld surface analysis, and 1D helical supramolecular structure of a novel binuclear copper(ii) Schiff base complex

“…Each assay in this experiment was repeated twice. 45,46 2.5.2 Micro dilution assays. The minimal inhibition concentration (MIC) values, except one, were also studied for the microorganisms sensitive to compound determined in the disc diffusion assay.…”

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

“…Schiff base has the highest activity against Bacillus megaterium. All of the complexes have a remarkable decrease in antibacterial activities than Schiff base [34]. Narendra Kumar Chaudhary and Parashuram Mishra have synthesized a series of three new metal(II) complexes of Schiff base from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio.…”

A Comprehensive Review on Synthesis and Biological Activity of Schiff Bases

“…R-CH=NR' where R' ≠ H). 1 The significance of Schiff bases and their metal complexes are significant as analgesic 2-3 , anti-inflammatory [4][5][6][7][8] , anticancer [9][10][11][12][13] , anticonvulsant 14 and antimicrobial activities [15][16][17][18][19][20][21][22][23][24] .…”