The Synthesis, Characterization and Photophysical Properties of Some New Cyclotriphosphazene Derivatives Bearing Schiff Base

Abstract

Hexa(2-formylphenoxy)cyclotriphosphazene (o-CHO-C 6 H 4 O) 6 N 3 P 3 (2) was obtained from the reaction of hexachlorocyclotriphosphazene (1) with salicylaldehyde in the presence of K 2 CO 3 in THF solvent. A series of Schiff bases containing cyclotriphosphazenes such as [

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

“…The reaction of aryloxycyclophosphazenes containing aldehyde group with primary amines, the reaction of halocyclophosphazenes with Schiff bases bearing hydroxy, and the reaction of aldehydes with amine bonded aryloxycyclophosphazenes (achieved by the catalytic reduction of phosphazene containing nitrophenoxy). Schiff bases have a variety of applications in fields such as flame resistance, biomedicine, semi‐conductors, dyes, and catalysis 42. Antiproliferative activity of phosphazenes containing Schiff bases was observed to be much higher against cancer cells than the normal cells 42.…”

Formation of novel spiro, spiroansa and dispiroansa derivatives of cyclotetraphosphazene from the reactions of polyfunctional amines with octachlorocyclotetraphosphazatetraene

“…(δ = 1⋅06 (P A ) (PNspiro) and -3⋅34 ppm (P B )(PCl 2 )), but the two coupling constant of P(Nspiro-PCl 2 )(P A P B ) is 28⋅5 Hz similar to that of (14). 35 The proton coupled 31 P NMR spectrum (not shown) of (11) shows that the spermine replaces four chlorine atoms in compound (1). Two different singlets are seen as multiplets (P A ) and triplet (P B ).…”

“…35 The proton coupled 31 P NMR spectrum (not shown) of (3) shows that the compound (2) replaces two the chlorine atoms in compound (1). The signals at ca.…”

“…35 The doublet at δ = -3⋅71 ppm is caused by PCl 2 group (P D ) in figure 4a and the coupling constant of this group was calculated as 2 JP C P D = 22⋅4 Hz (table 4). The proton coupled 31 P NMR spectrum of (8) show that the spermidine replaces three chlorine atoms in compound (1). The signals at ca.…”

“…14 The reactions of hexachlorocyclotriphosphazatriene, N 3 P 3 Cl 6 , with di-, tri-and tetra-functional amines have been extensively studied [15][16][17][18] and especially large difunctional diamines were reported for a potential value in cancer chemotherapy as selective carriers for delivering anticancer drugs to malignant target cells. 19,20 Although, a large number of octachlorocyclotetraphosphazatetraene (1), N 4 P 4 Cl 8 , with monofunctional amines were prepared and studied, 21-31 discussion on a substitution with polyfunctional amines is relatively limited in the literature. [32][33][34][35][36][37] We report here, the synthesis and structural characterization of six new cyclotetraphosphazene derivatives (scheme 1) and, to the best of our knowledge, there is no report so far of any derivative in this series that has been structurally characterized by any spectral data or x-ray crystallography.…”