The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, andin vitrocytotoxic activities of novel parent and niosome nano-encapsulated Ho(iii) complexes

Abstract

A new complex of holmium, [Ho(bpy)(H2O)6]Cl3 has been synthesized, their DNA/BSA/HSA binding, molecular docking, antibacterial activity and MTT assay of niosome nano-encapsulated are investigated.

Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques

“…The flow time was measured using a digital stopwatch and each sample was tested three times to get accurate outcomes. The relative viscosity was determined using the following relation 45 where ƞ and ƞ o defines the viscosities of DNA in the presence and absence of 4g respectively, t DNA is the average flow time of pure DNA, t complex is the average flow time of DNA in the presence of 4g at varying concentration, and t o be the flow time of Tris–HCl buffer 46 . If a ligand binds via intercalary mode an increase in viscosity will be observed however, no effect on viscosity will be detected in case of groove binders 47 .…”

A DNA Biosensor Based on a Raspberry‐like Hierarchical Nano‐structure for the Determination of the Anticancer Drug Nilotinib

“…In this sense, a classical intercalative binding of small molecules usually results in the increased viscosity of DNA solution. Reversely, non‐intercalation binding like electrostatic or groove bindings can only partly influence DNA viscosity because they do not make changes in the axial length of ds‐DNA during the binding [53] . With regard to Figure 8, the relative viscosity of ds‐DNA exhibits only minor changes, showing that the binding mode of nilotinib with ds‐DNA is not an intercalative interaction.…”

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

“…24 The anticancer properties of the terbium complexes, LNEP and SNEP, were studied by MTT examination on the A-549 and MCF-7 cell lines, as explained previously. 9 The unwanted cytotoxicity potential of these compounds was also studied on normal human broblast (HFB) cells. These cell lines were incubated for one day in a humidied 5% CO 2 incubator at 37 C, in the presence of different concentrations of the Sm complex, SNEP, and LNEP.…”

“…[1][2][3][4][5][6][7] The binding of lanthanide compounds with macromolecules (e.g., DNA and proteins) is an exciting part for both biochemists and inorganic chemists. 8,9 The interactions of compounds with DNA propose that these compounds can have potential pharmaceutical and biological activities that depend on the affinity of the interaction mode with DNA. When designing potential antitumor factors, nonintercalation compounds are more favorable than intercalation compounds.…”