The synthesis, coordination chemistry and ethylene polymerisation activity of ferrocenediyl nitrogen-substituted ligands and their metal complexes

Gibson, Vernon C.; Gregson, Charlotte K. A.; Halliwell, Catherine; Long, Nicholas J.; Oxford, Philip J.; White, Andrew J. P.; Williams, David J.

doi:10.1016/j.jorganchem.2005.05.051

Cited by 40 publications

(24 citation statements)

References 51 publications

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“…The cyclopentadienyl rings are staggered [torsion angle N–C ipso –C ipso –N 23.1(2)°] and the p ‐phenylene rings are approximately parallel, forming angles of 6.12(15) and 10.21(15)° with the planes of their parent cyclopentadienyl rings. These structural features resemble those reported by Gibson, Long and co‐workers for [fc(N=CHAr) 2 ] (Ar = 3‐anthracen‐9‐yl‐2‐hydroxyphenyl) 28. Compound 1b also has two independent molecules in the asymmetric unit that adopt very similar conformations, resembling that of the approximately C 2 ‐symmetric molecule 2 of compound 1a .…”

Section: Resultssupporting

confidence: 82%

“…Only a single 1,1′‐diiminoferrocene derivative with aryl substituents has been structurally characterised to date 28. The asymmetric unit of 1a contains two independent molecules that exhibit very similar bond lengths and angles, but differ significantly in the relative orientation of the imino substituents and the conformation of the ferrocene unit (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

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Ferrocene‐Based N‐Heterocyclic Carbenes with Functionalised Benzyl Substituents

2015

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We describe herein N-heterocyclic carbenes (NHCs) with a 1,1Ј-ferrocenylene backbone that contain substituents at the nitrogen atoms relevant for applications in the area of metallopharmaceuticals, namely benzyl units functionalised with dimethylamino and methoxy groups at the para position. These carbenes are too unstable for isolation. They were generated from the corresponding formamidinium tetrafluoroborates by deprotonation and efficiently trapped in situ. Trapping with elemental selenium afforded the corre-

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Ferrocene‐Based N‐Heterocyclic Carbenes with Functionalised Benzyl Substituents

2015

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“…In general, the signal for the iminic proton CH=N in the 1 H NMR appeared as a singlet between 8.84 and 9.05 ppm (Table 3) in accordance with other reported bis(imino)pyridine and related ligands [44][45][46] . The aromatic ring of the bis(imino)benzene ligands (3a-e), was observed as an AB 2 C system.…”

Section: Resultssupporting

confidence: 89%

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Iglesias¹,

Miranda-Soto²,

Pompa-Monroy³

et al. 2019

pharmaceutical-sciences

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Treatment of infectious diseases is an ever-increasing problem owing to the growing number of multi-drug resistant pathogens. Nosocomial infections are on the rise due to antibiotic-resistant microorganisms, which have led to increased morbidity and mortality in many hospitals. Cancer is a major disease worldwide [1] ; colorectal cancer particularly, is the second leading cause of death by cancer in Western countries and has one of the highest mortality rates in both men and women. These cancer patients are especially susceptible to nosocomial infections; as a result of their immunosuppressed systems (due to the treatments associated with illness); which in turn leads to prolonged stays, disability and economic burden [2,3]. Therefore, the search for novel compounds that displayed a broad range of therapeutic activities that can address these major health problems is of outmost importance [4]. New therapeutic drugs that contain a heterocyclic core are on the forefront of pharmaceutical research [5,6]. Pyrazoles, (1,2-azoles) have proven to be a remarkable scaffold for the synthesis of biologically active compounds [7-9] thanks to their wide range of medical applications that center mainly on antimicrobial [10-12] , antifungal [8,12,13] , antiinflammatory [7] , analgesic, and anxiolytic activities [13,14]. Some pyrazole derivatives have also shown antitumor activities towards several cancer cell lines, including leukemia (K562), HeLa cervix adenocarcinoma and Fem-x melanoma [14]. Consequently, in recent years pyrazole-base compounds have become a target of great interest.

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“…1), offering possible isomerization processes during the polymerization reaction. In contrast, ancillary stereorigid tetradentate dianionic ( À O,N,N,O À ) Schiff-base-donor-group 4 complexes [25][26][27][28][29][30][31][32][33][34][35], with steric hindrance on phenoxo moieties and exhibiting at least two heteroatoms set in a cis-position, avoid these isomerization processes, consequently reducing the presence of stereoisomers (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%