The synthesis of [1‐¹⁴C]2‐(1H‐tetrazol‐5‐yl)acetic acid

Abstract

Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1- C]2-(1H-Tetrazol-5-yl)acetic acid was required as an intermediate in the synthesis of a development candidate as part of a discovery phase program to complete metabolic profiling studies. [1- C]2-(1H-Tetrazol-5-yl)acetic acid was prepared in 4 steps overall and in 3 radiochemical steps from K CN in an overall 32% radiochemical yield.