The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

Convenient and Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives and Their Anticancer Activities

“…2,3-Dihydroquinazolin-4(1H)-one derivatives are an important class of fused Ncontaining heterocycles with various biological, medicinal, and pharmacological activities such as antitumor [3] , antibiotic [4] , antifungal [5] , analgesic [6] , diuretic [7] , antifertility [8] , antidepressant [9] , antihistaminic [10] , vasodilating [11] , and antifibrillatory agent [12] . In addition, these compounds can act as potent tubulin inhibitors with promising anti-proliferative activity against several human cancer cell lines [13] .…”

LaCl3/nano-SiO2: A novel nanocatalyst for efficient synthesis of functionalized 2,3-dihydroquinazolinones

“…2,3-Dihydroquinazolinones represent a family of drugs that are used as anticancer, antibiotic, anti-inflammatory, analgesic, diuretic, antidepressant, and antitubercular behaviour [5][6][7][8][9][10].…”

Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst

“…These are widely used in biological and pharmaceutical activities [1]. The quinazolinones display wide range of biological activities such as antitumor [2,3], antidefibrillatory [4], antidepressant [5], analgesic [6], diuretic [7], antihistamine [8], vasodilating [9], antihypertensive [10], CNS stimulant [11], tranquilizing [12] and antianxietic [13]. Some representative drug molecules having quinazoline skeleton are shown in Figure 1.…”