The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity

2-Arylindoles: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activity

“…(4)) displays an MIC value of 625 g/mL against Cryptococcus neoformans, whilst an analogue which has a single methoxy group at C-4 of the 2-aryl group (not the indole ring) has an MIC value of 58.5 g/mL against the same pathogen [28]. A series of other substituted 2-arylindoles and their activity against bacterial and yeast cell lines have also been reported.…”

“…(4)) gives rise to antifungal activity against Cryptococcus neoformans with an MIC value of 313 g/mL not previously present in compounds lacking these methoxy groups, whereas the addition of an extra methoxy group at position-5 increases the antifungal activity against this species to 32.5 g/mL (C in Fig. (4)) [28]. Fig.…”

Copper‐Catalyzed Direct Synthesis of 3‐Arylindoles

“…[2] Various 2-and 3-arylindoles display significant antimicrobial activity against the Gram-positive microorganism Bacillus cereus. [3] Substituted indole INF55 is a promising lead in helping a wide range of antibiotics stay in bacterial cells. [4] Some aryl-substituted indoles have been implicated in the inhibition of bacterial histidine kinases.…”

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“…Compounds having pharmacophore such as chloro, fluoro, and bromo groups have exhibited best anti-convulsants 11 , antiinflammatory 12 , anticancer 13 , antitubercular 14 , antibacterial activity 15 , antifungal 16 , and antihistaminic 17 . From the above discussions it may be concluded that the modifications in bis (indolyl) moiety displayed valuable biological activities and these modifications can be utilized to develop potentially active agents.…”