The Synthesis of an Antiviral Fluorinated Purine Nucleoside: 3'-α-Fluoro-2',3'-dideoxyguanosine

Izawa, Kunisuke; Torii, Takayoshi; Onishi, Taku; Maruyama, Toru

doi:10.1021/bk-2007-0949.ch022

Cited by 2 publications

(2 citation statements)

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“…Zalcitabine ( 34 ) is a dideoxynucleoside with cytosine as a base and differs only from didanosine ( 21 ) in that it is a base, so the detailed inhibition mechanism and synthesis method will be omitted. Alovudine ( 35 ) [23–26] will be introduced at a later stage. Unlike these dideoxynucleosides, lodenosine ( 36 ) is characterized by its stability under acidic conditions.…”

Section: Nrtis That Target Hiv‐1mentioning

confidence: 99%

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Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)

et al. 2021

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Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS remains a serious disease that causes many deaths annually. Although a variety of anti‐HIV drugs have been synthesized and marketed to treat HIV‐infected patients, nucleoside analogue reverse transcriptase inhibitors (NRTIs), which mimic nucleosides, are used extensively and remain a subject of interest to medicinal chemists. However, HIV has acquired drug resistance against NRTIs, and thus the struggle to find novel therapies continues. In this review, we trace the trajectory of NRTIs, focusing on the synthesis, mechanisms of action and applications of NRTIs that have been developed.

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Section: Nrtis That Target Hiv‐1mentioning

confidence: 99%

“…the detailed inhibition mechanism and synthesis method will be omitted. Alovudine (35) [23][24][25][26] will be introduced at a later stage. Unlike these dideoxynucleosides, lodenosine (36) is characterized by its stability under acidic conditions.…”

Section: Synthetic Scheme Of Didanosine and Its Applicationmentioning

confidence: 99%