The synthesis of androstane brassinosteroid analogues with α-azido acid ester groups in position 17β

Quality and Selected Metals Content of Spring Wheat (Triticum aestivum L.) Grain and Biomass After the Treatment with Brassinosteroids During Cultivation

“…Their increase in net photosynthetic rate due to brassinosteroids application has already been observed in wheat, tomato and cucumber under normal condition and environment stresses (Ogweno et al, 2008;Shabaz et al, 2008;Xia et al, 2009;Yuan et al, 2010, Holá, 2010. Nowadays biological effects not only naturally occurring brassinosteroids, but also their androstane and pregnane analogues are widely synthesised and their biological effects studied (Hniličková et al, 2010) as well as their miscellaneous metabolic pathways in plants involving dehydrogenation, demethylation, epimerization, esterification, glycosylation, hydroxylation, side-chain cleavage and sulfonation (Bajguz, 2007). Because brassinosteroids control several important agronomic traits (Kang & Guo, 2010) such as flowering time, plant architecture, seed yield and stress tolerance, the genetic manipulation of brassinosteroids biosynthesis, conversion or perception offers a unique possibility of both changing plant metabolism and protecting plants from environmental stresses confirming the value of further research on brassinosteroids to improve productivity and quality of agricultural crops (Divi & Krishna, 2009) or their possible use for phytoremediation application (Barbafieri & Tassi, 2010).…”

Synthetic Aspects of Brassinosteroids

“…It is interesting that the dilactone (256) was the most active in the bean second internode bioassay among the compounds tested, while similar monolactone (257) showed retarding effects. The choice of the azides (260) as a synthetic target was based on the results of computational studies [116] that predicted a high biological activity of compounds having a keto group at C-22 and an azido group at C-23. Despite their biological activity was reduced compared to the natural BS, some interesting tendencies were found concerning substituents at C-16 and C-17.…”