2007
DOI: 10.1002/jlcr.1399
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The synthesis of dopaminergic radioligands labelled with tritium and iodine‐125

Abstract: The preparation of dopaminergic ligands radiolabelled with either tritium or iodine-125 has been an extremely important undertaking to advance understanding of this critical receptor class and the topic is reviewed from 1976 through 2006. Although not an exhaustive compilation of references, the cited examples highlight the many methods employed to prepare these useful reagents.

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Cited by 4 publications
(4 citation statements)
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References 96 publications
(63 reference statements)
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“…Filer [ 56 ] presented a number of examples of using tritium NMR for the identification of dopaminergic radioligands labeled with tritium to advance understanding of their biological action. One of the most illustrative examples is presented in Figure 35 showing proton decoupled tritium NMR spectrum of [benzoyl‐3,4‐3H]cocaine, obtained using a convenient dichlorophenyl precursor, which demonstrates exclusive aromatic tritium labeling.…”
Section: More Recent Resultsmentioning
confidence: 99%
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“…Filer [ 56 ] presented a number of examples of using tritium NMR for the identification of dopaminergic radioligands labeled with tritium to advance understanding of their biological action. One of the most illustrative examples is presented in Figure 35 showing proton decoupled tritium NMR spectrum of [benzoyl‐3,4‐3H]cocaine, obtained using a convenient dichlorophenyl precursor, which demonstrates exclusive aromatic tritium labeling.…”
Section: More Recent Resultsmentioning
confidence: 99%
“…Tritium proton decoupled NMR spectrum of [benzoyl‐3,4‐3H]cocaine recorded in CD 3 OD at 320 MHz. Reproduced with minor editing privilege from Filer [ 56 ] with the permission of John Wiley and Sons…”
Section: More Recent Resultsmentioning
confidence: 99%
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“…Tritium ( 3 H). The various solid-state reactions 52 that can be used to make tritium labelled organic compounds have been reviewed as have routes 53 to tritium labelled dopamines. For the most part tritium labelling can be achieved by standard organic procedures such as the use of [ 3 H]methyl iodide (dinucleotides), 54 catalytic reduction with [ 3 H]hydrogen (carbohydrates), 55,56 or the use of tritiated reducing agents such as lithium tritide (dimethylditritiogermane), 57 sodium [ 3 H]borohydride (puerarin 58 -an isoflavine C-glycoside and PR-104, 59 a hypoxia-activated pre-prodrug) or lithium [ 3 H]aluminohydride (phosphoramide 60 derivatives).…”
Section: Isotopesmentioning
confidence: 99%