The synthesis of isomeric 4- and 6-ethoxy-3-ethylpyridines

Yakhontov, L. N.; Lapan, E. I.; Rubtsov, M. V.

doi:10.1007/bf00474882

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…According to the literature data for the preparation of 4-aminopiperidine the reaction of the reduction of oximes to amines is used or the catalytic process, or lithium aluminum hydride [96][97], and also aminopyridines [98], nicotinic acid and its derivatives [99]. There are established methods for the preparation of 4-aminopiperidine substituted by halogen atom in the 4-halogen piperidine with ammonia and also from piperidin-4-ones by carrying out a reductive amination reaction in the presence of a nickel catalyst [100].…”

Section: Synthesis Of 1-methyl-4-(2-tiopikolinamino) -Piperidine (Altmentioning

confidence: 99%

Growth Stimulant Agents and Bactericides

Akbasova¹,

Sainova²

2015

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Moscow 2015Рекомендовано УМО РАЕ по классическому университетскому и техническому образованию в качестве учебного пособия для студентов высших учебных заведений, обучающихся по специальности 030016 -«Экология» UDC 574.5: 502/504(038) А38The monograph was prepared with the fi nancial support

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Section: Synthesis Of 1-methyl-4-(2-tiopikolinamino) -Piperidine (Altmentioning

confidence: 99%

Growth Stimulant Agents and Bactericides

Akbasova¹,

Sainova²

2015

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Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands

et al. 2019

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μ opioid receptor (MOR) agonists have been widely applied for treating moderate to severe pain. However, numerous adverse effects have been associated with their application, including opioid-induced constipation (OIC), respiratory depression, and addiction. On the basis of previous work in our laboratory, NAP, a 6β-N-4′-pyridyl substituted naltrexamine derivative, was identified as a peripheral MOR antagonist that may be used to treat OIC. To further explore its structure–activity relationship, a new series of NAP derivatives were designed, synthesized, and biologically evaluated. Among these derivatives, NFP and NYP significantly antagonized the antinociception effect of morphine. Whereas NAP acted mainly peripherally, its derivatives NFP and NYP actually can act centrally. Furthermore, NFP produced significantly lesser withdrawal symptoms than naloxone at similar doses. These results suggest that NFP has the potential to be a lead compound to treat opioid abuse and addiction.

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The synthesis of isomeric 4- and 6-ethoxy-3-ethylpyridines

Cited by 2 publications

References 3 publications

Growth Stimulant Agents and Bactericides

Growth Stimulant Agents and Bactericides

Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands

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