The synthesis of new fluorescent bichromophoric compounds as ratiometric pH probes for intracellular measurements

Abstract

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Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides

“…Compound 14 is a bichromophoric pH probe that contains two fluorophores (anthracene and dansyl) linked by a flexible pseudopeptidic spacer containing the amino acid valine (Figure 3). [13] The emission of 14 in the neutral-basic pH region is that arising from the dansyl chromophore (a strong and broad band centered at 490 nm), whereas in the acidic pH region, the prevalent emission is due to the anthracene chromophore (centered at 420 nm). These results conclude that compound 14 is a dual fluorescence pH probe which is able to emit in two different spectral regions as a function of the pH of the medium thus enabling the possibility of ratiometric measurements.…”

Photoreactivity of an Exemplary Anthracene Mixture Revealed by NMR Studies, including a Kinetic Approach

“…This includes various polymeric materials [30,31], such as intelligent shape memory polymers [32], as well as soft materials, such as photoresponsive hydrogels [16] and liquid crystals [33]. Hence, the main applications cover a vast number of fields, including tissue engineering [30], optoelectronic devices [33] such as organic light-emitting diodes or transistors [34], sensors for metal ion detection [35], molecular containers for catalysis or drug delivery [36] and photomedicine, where these compounds can be used as intracellular pH probes [37], DNA-based hybridization sensors [38] and other biosensors [39]. According to the latest results, anthracene derivatives have even been suggested as potential candidates for applications in laser photonics [40] and as smart optical materials [41].…”

Acid–Base Behaviour in the Absorption and Emission Spectra of Ruthenium(II) Complexes with Hydroxy‐Substituted Bipyridine and Phenanthroline Ligands

“…The pH of an aqueous medium plays an indispensable role in many chemical, environmental and biological processes and thus it is of great importance to develop various tools or methodologies for the determination of pH, A wide variety of methods have been developed for the monitoring of pH . Among these methods, optical pH sensors have attracted considerable attention because of their high sensitivity as well as their real time and fast responses , .…”