The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents

Drew, Michael G. B.; Gorsuch, Stephen; Gould, Jayne; Mann, John

doi:10.1039/a900800d

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Cited by 6 publications

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“…The best ones proved to be boron trifluoride in dichloromethane (condition A) and TMSOTf in acetonitrile (condition B). The nucleophiles were prepared from thymine and cytosine by using the Vorbrüggen protocol, since the commercial reagents gave inferior results …”

Section: Resultsmentioning

confidence: 99%

One-Pot Synthesis of Acyclic Nucleosides from Carbohydrate Derivatives, by Combination of Tandem and Sequential Reactions

Boto

Hernández

et al. 2007

J. Org. Chem.

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The design of processes which combine tandem and sequential reactions allows the transformation of readily available precursors into high-profit products. This strategy is illustrated by the one-pot synthesis of acyclic nucleosides, which are potential antiviral compounds, from readily available carbohydrates. The reaction conditions are mild, compatible with most functional groups. Depending on the starting sugar, both common and uncommon acyclic chains can be prepared. These polyhydroxylated chains can be combined with different bases to generate diversity.

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Section: Resultsmentioning

confidence: 99%