1977
DOI: 10.1111/j.1432-1033.1977.tb11316.x
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The Synthesis of Several 8-Substituted Derivatives of Adenosine 5'-Monophosphate to Study the Effect of the Nature of the Spacer Arm in Affinity Chromatography

Abstract: Reaction of adenosine 5'-monophosphate (Ado-5'-P) with bromine at pH 4.0 yielded 8-bromoadenosine 5'-monophosphate and following reaction with several @,coo-diaminoalkanes gave the corresponding 8-(co-aminoalkyl)-Ado-5'-P derivatives. Condensation of these analogues with N-trifluoroacetyl-glycine or /I-alanine in the presence of a water-soluble carbodiimide generated several 8-substituted derivatives. These analogues : I OH comprised an %substituted Ado-5'-P ligand to which a spacer molecule of similar length … Show more

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Cited by 45 publications
(24 citation statements)
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“…The column was washed with water (2 1) to remove unreacted 1,6-diaminohexane until the effluent was negative to the trinitrobenzene sulphonate test [14,18]. No ultraviolet-absorbing material was found in the washings.…”
Section: Analytical Proceduresmentioning
confidence: 99%
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“…The column was washed with water (2 1) to remove unreacted 1,6-diaminohexane until the effluent was negative to the trinitrobenzene sulphonate test [14,18]. No ultraviolet-absorbing material was found in the washings.…”
Section: Analytical Proceduresmentioning
confidence: 99%
“…cm-' at 250 nm and Base-Substituted AMP Ligands (Fig. 1 C, D ) The synthesis and characterisation of N6-(6-aminohexy1)-adenosine 5'-monophosphate (Ahx6AMP) and 8-(6-aminohexyl)-adenosine 5'-monophosphate (Ahx*-AMP) was performed as described previously [14,18]. In each case, the diaminoalkane 1,6-diaminohexane, was purified by distillation under reduced pressure prior to use.…”
Section: Synthesis Of Znosinementioning
confidence: 99%
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