The Synthesis of Substituted Biurets

A number of arylbiurets were prepared and evaluated as antiinflammatory and analgesic agents by using the carrageenan paw edema and acetic acid stretching tests. Among them, the antiinflammatory activity of 1,3-dimethyl-5-phenylbiuret (7), 1-ethyl-3-methyl-5-phenylbiuret (11), and 1,1,3-trimethyl-5-phenylbiuret (13) were found to be more potent than phenylbutazone. The analgesic activity of 7 and of 5-(4-chlorophenyl)-1,1,3-trimethylphenylbiuret (16) is higher than that of aminopyrine.

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Syntheses, Antiinflammatory, and Analgesic Activities of Arylbiurets

Yamazaki

Yamada

Tanaka

et al. 1990

Archiv der Pharmazie

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Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

Fouladdel¹,

Khalaj²,

Adibpour³

et al. 2010

Bioorganic & Medicinal Chemistry Letters

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The Synthesis of Substituted Biurets

Abstract: not available

Cited by 2 publications

References 3 publications

Syntheses, Antiinflammatory, and Analgesic Activities of Arylbiurets

Syntheses, Antiinflammatory, and Analgesic Activities of Arylbiurets

Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

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