The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury

Duran, Raquel Cuevas-Diaz; Yan, Han; Zheng, Yiyan; Huang, Xingfan; Grill, Raymond J.; Kim, Dong H.; Cao, Qilin; Wu, Jia Qian

doi:10.1038/srep41008

Cited by 49 publications

(66 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, it has been shown that lncRNA UCA1 can regulate neural stem cell differentiation by regulating miR‐1/Hes1 expression (Zheng et al, ). As well known, SCI is one of the most debilitating neurological diseases and most of SCI patients remain in the chronic phase (Duran et al, ). XIST contributes to the pathogenesis of SCI by sponging miR‐494 and regulating PTEN/AKT signaling axis and it is suggested that XIST can serve as a promising molecular target for treating SCI (Gu et al, ).…”

Section: Discussionmentioning

confidence: 99%

XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models

Yan

Wang

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

LncRNAs are reported to participate in neuropathic pain development. LncRNA X-inactive specific transcript (XIST) is involved in the progression of various cancers. However, the role of XIST in neuropathic pain remains unclear. In our present study, we established a chronic constriction injury (CCI) rat model and XIST was found to be greatly upregulated both in the spinal cord tissues and in the isolated microglias of CCI rats. Inhibition of XIST inhibited neuropathic pain behaviors including mechanical and thermal hyperalgesia. Moreover, decrease of XIST repressed neuroinflammation through inhibiting COX-2, tumor necrosis factor (TNF)-α and IL-6 and in CCI rats. Previously, miR-150 has been reported to restrain neuropathic pain by targeting TLR5. Currently, miR-150 was predicted to be a microRNA target of XIST, which indicated a negative correlation between miR-150 and XIST. miR-150 was remarkably decreased in CCI rats and overexpression of miR-150 can significantly suppress neuroinflammation-related cytokines. Furthermore, ZEB1 was exhibited to be a direct target of miR-150 and we found it was overexpressed in CCI rats. Silencing ZEB1 was able to inhibit neuropathic pain in vivo and downreguation of XIST decreased ZEB1, which can be reversed by miR-150 inhibitors. Taken these together, we indicated that XIST can induce neuropathic pain development in CCI rats via upregulating ZEB1 by acting as a sponge of miR-150. It was revealed that XIST/miR-150/ZEB1 axis can be provided as a therapeutic target in neuropathic pain.

show abstract

Section: Discussionmentioning

confidence: 99%

XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models

Yan

Wang

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Adapted from Duran et al . with modifications and permission. ( B ) Left panel: Browser view depicting the gene expression of DE lnc RNA LOC 100912503 and its closest DE protein‐coding gene Bmpr1a at different time points of the subchronic and chronic stages of rat SCI .…”

Section: Functions Of Lncrnas In Acute and Chronic Cns Injuriesmentioning

confidence: 99%

“…LncRNAs are in blue and proteincoding genes are in red colour. Adapted from Duran et al[24] with permission and modifications.…”

mentioning

confidence: 99%

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Durán

Wei

Kim

et al. 2019

Neuropathology Appl Neurobio

View full text Add to dashboard Cite

Genome‐wide transcriptional studies have demonstrated that tens of thousands of long non‐coding RNAs (lncRNA) genes are expressed in the central nervous system (CNS) and that they exhibit tissue‐ and cell‐type specificity. Their regulated and dynamic expression and their co‐expression with protein‐coding gene neighbours have led to the study of the functions of lncRNAs in CNS development and disorders. In this review, we describe the general characteristics, localization and classification of lncRNAs. We also elucidate the examples of the molecular mechanisms of nuclear and cytoplasmic lncRNA actions in the CNS and discuss common experimental approaches used to identify and unveil the functions of lncRNAs. Additionally, we provide examples of lncRNA studies of cell differentiation and CNS disorders including CNS injuries and neurodegenerative diseases. Finally, we review novel lncRNA‐based therapies. Overall, this review highlights the important biological roles of lncRNAs in CNS functions and disorders.

show abstract

“…These results suggested that lncRNA expression was highly dynamic across different stages. Nonetheless, these studies have aimed to reveal the lncRNA profiles in different post‐injury time‐points, from immediate, acute, subchronic to chronic phases after SCI (Figure ). These studies provided preliminary views on stage‐specific lncRNA modulation.…”

Section: Lncrna Expression Profiling In Scimentioning

confidence: 99%

Long non‐coding RNAs in the spinal cord injury: Novel spotlight

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non‐coding RNAs (lncRNAs) are abundant in the brain and might play critical roles in several nervous system disorders. At the cellular level, lncRNAs have been shown to regulate the expression of protein‐coding RNAs and hence participate in neuronal death, demyelination and glia activation. Notably, SCI is characterized by these biological processes, suggesting that lncRNAs could be novel modulators in the pathogenesis of SCI. This review describes recent progresses in the lncRNA transcriptome analyses and their molecular functions in regulating SCI progression.

show abstract

The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury

Cited by 49 publications

References 71 publications

XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models

XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Long non‐coding RNAs in the spinal cord injury: Novel spotlight

Contact Info

Product

Resources

About