The T-SPOT.TB Test for Diagnosis of Breast Tuberculosis

Zhong, Lei; Zhou, Xinglu; Li, Juan; Zhang, Yanmei; Jiao, Yu‐Fei; Guo, Baoliang; Yan, Zhaoqi; Zhang, Jianguo

doi:10.1309/lmfbrt05mwv3ayim

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…However, there was no significant difference in the positive rate of T‐SPOT.TB between the two groups, suggesting the immunosuppressive state has little effect on the diagnostic sensitivity of T‐SPOT.TB. The results were similar to the previous studies 3,29,30 …”

Section: Discussionsupporting

confidence: 93%

Comparison of diagnostic accuracy of QuantiFERON‐TB Gold Plus and T‐SPOT.TB in the diagnosis of active tuberculosis in febrile patients

Zhang

Yang

Bao

et al. 2022

J Evidence Based Medicine

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Objective: This study aimed to compare the accuracy of QuantiFERON-TB Gold Plus (QFT-Plus) and T-SPOT.TB for diagnosing active tuberculosis (ATB) in febrile patients, to explore influencing factors of positive results and to verify the potential value of QFT-Plus in the identification of ATB and latent tuberculosis infection (LTBI). Methods: A total of 240 febrile patients with ATB (n = 80) and non-ATB (n = 160) were recruited to assess the accuracy of QFT-Plus and T-SPOT.TB for diagnosing ATB. Multivariable logistic regression was used to analyze the influencing factors of positive results. Results: The proportion of indeterminate results (ITRS) in QFT-Plus and T-SPOT.TB were 3.3% and 0%, respectively. The consistency between the results of the QFT-Plus and T-SPOT.TB was substantial. The area under the receiver operating characteristic curve (AUROC) of the QFT-Plus and T-SPOT.TB for diagnosing ATB was 0.792

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Section: Discussionsupporting

confidence: 93%

Comparison of diagnostic accuracy of QuantiFERON‐TB Gold Plus and T‐SPOT.TB in the diagnosis of active tuberculosis in febrile patients

Zhang

Yang

Bao

et al. 2022

J Evidence Based Medicine

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“…T SPOT is an excellent biomarker for diagnosis of active TB [21] and breast TB [22]. Zhu and his colleagues showed T-SPOT to be suitable for screening extra-pulmonary TB, including pleurisy TB [23].…”

Section: Discussionmentioning

confidence: 99%

The diagnostic effect of sequential detection of ADA screening and T-SPOT assay in pleural effusion patients

Mao

Sun

Wang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Purpose: To evaluate the diagnostic effect of sequential detection of Adenosine deaminase (ADA) screening and T-SPOT assay on tuberculosis (TB) pleurisy in pleural effusion patients. Materials and methods: 248 pleural effusion patients (172 TB and 76 non-TB) were retrospectively analyzed in the study. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. T-SPOTT assays were performed in pleural fluids. The relationship between ADA, T-SPOT and the occurrence of TB pleurisy was evaluated using logistic regression analysis. Results: The level of pleural ADA and positive rate of T-SPOT were all higher in TB pleurisy group than non-TB pleurisy group (p < .001). The positive rate of T-SPOT detection reached 98.83% in the TB pleurisy group while only 40.7% in non-TB pleurisy group (p < .001). Additionally, 8 patients (4.65%) in the TB pleurisy group showed the level of pleurisy ADA exceeded 40 IU/L while only one patient (1.31%) in the non-TB pleurisy group. Conclusion:The sequential detection of ADA screening and T-SPOT assay was found to be an accurate and rapid method for identifying TB pleurisy from pleural effusion, which would promote effective treatment.

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“…Zong et al in their short series of 13 patients with primary breast TB used T-SPOT.TB test for diagnosis of breast TB. In their series, T-SPOT.TB had sensitivity of 84.6% and specificity of 80.0% [17]. Researchers have started experimenting GX test for diagnosis of extrapulmonary tuberculosis from samples such as urine, CSF, pleural fluids, and lymph nodes [5].…”

Section: Discussionmentioning

confidence: 99%

Role of GeneXpert MTB/RIF Assay for Diagnosis of Tuberculous Mastitis

2019

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The role of GeneXpert MTB/RIF (GX) in tuberculous (TB) mastitis is not defined. The aim of this study was to evaluate the role of GX in the diagnostic evaluation of TB mastitis. Patients presenting with signs and symptoms of breast abscess, previously drained breast abscess that did not heal, and recurrent breast abscesses were included in the study. GX (cartridge-based nucleic acid amplification test), FNAC, abscess wall scrapings for histopathology, pus for culture and sensitivity, chest X-ray, serum adenosine deaminase (ADA), and ESR levels were performed in all patients. Female patients (n = 228) were enrolled in the study between August 2013 and December 2017. A total of 26 (11.4%) patients were diagnosed with TB mastitis using multiple clinical/biochemical/histopathological parameters. GX was positive for Mycobacterium TB (MTB) in 22 patients whereas FNAC and combined ADA+ESR (ADA > 23.5, ESR > 25) were suggestive of TB mastitis in 6 and 18 patients respectively. The sensitivity, specificity, positive predictive value, and negative predictive value for GX test, FNAC, and combined ADA+ESR were 83.3%,

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The T-SPOT.TB Test for Diagnosis of Breast Tuberculosis

Abstract: The T-SPOT.TB test could be a useful adjunct to current tests for diagnosis of BTB and could be used for early diagnosis of this condition.

Cited by 7 publications

References 19 publications

Comparison of diagnostic accuracy of QuantiFERON‐TB Gold Plus and T‐SPOT.TB in the diagnosis of active tuberculosis in febrile patients

Comparison of diagnostic accuracy of QuantiFERON‐TB Gold Plus and T‐SPOT.TB in the diagnosis of active tuberculosis in febrile patients

The diagnostic effect of sequential detection of ADA screening and T-SPOT assay in pleural effusion patients

Role of GeneXpert MTB/RIF Assay for Diagnosis of Tuberculous Mastitis

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