The T1858 variant predisposing to the precore stop mutation correlates with one of two major genotype F hepatitis B virus clades

Nordér, Helené; Arauz‐Ruiz, Patricia; Blitz, Linda; Pujol, Flor H.; Echevarría, J M; Magnius, Lars O.

doi:10.1099/vir.0.19034-0

Cited by 43 publications

(32 citation statements)

References 32 publications

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“…This association was previously described for HBV-infected patients of Hispanic origin in Central America (6), where most genotype F strains contain T1858. However, in other Latin American populations, in which C1858 predominates in circulating strains of HBV, the association between the precore stop codon mutation and genotype F is not clear or is uncertain (28,48). Therefore, Argentinean strains of HBV genotype F were closer to those observed in Central America with respect to precore codon 28 status and may harbor T1858.…”

Section: Discussionmentioning

confidence: 96%

“…Genotype F has also been sporadically detected in samples from Brazil (17,45), North America (14, 47), Europe (21,48), and Polynesia (16). However, none of these reports focused on blood donors.…”

Section: Discussionmentioning

confidence: 97%

“…This specific hairpin structure is essential for the packaging of viral pregenomic RNA (29). In strains with the wild-type precore, nt 1858 shows complementarity with opposing nt 1896 (which is directly involved in the nonsilent mutation G1896A) and is found in close association with the HBV genotype (48,55). The presence of "C" at nt 1858 seems to be unfavorable to the development of a stop mutation due to its destabilizing effect on the stem of the encapsidation signal.…”

Section: Discussionmentioning

confidence: 99%

“…Genotype F, while being the most divergent HBV genotype (46), has also shown high intragroup variability and can be subdivided into different clades (41,42,48). When complete genome sequences were used for phylogenetic analyses, genotype F samples from Venezuela and Colombia clustered separately from those from Central America, a pattern resembling viral genetic subgrouping in these geographical regions (4).…”

Section: Discussionmentioning

confidence: 99%

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Strong Association between Genotype F and Hepatitis B Virus (HBV) e Antigen-Negative Variants among HBV-Infected Argentinean Blood Donors

et al. 2004

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A number of reports have indicated an increased risk of cirrhosis and hepatocellular carcinoma in hepatitis B virus (HBV)-infected individuals carrying HBV e antigen (HBeAg)-negative variants. Although distinct core promoter and precore mutations distributed according to geographical locality and viral genotype have been reported, epidemiological data from South America are still scarce. The prevalences of HBV genotypes and core promoter and precore polymorphisms in 75 HBeAg-negative Argentinean blood donors were surveyed. The observed frequencies of HBV genotypes were 64.0% for genotype F, 17.3% each for genotypes A and D, and 1.3% for genotype C. Genotype F strains were widely distributed and significantly more prevalent in the northern region of the country (P < 0.001). An overall high proportion of a stop codon mutation (UAG) at precore codon 28 (66.7%) was observed. Wild-type codon 28 (UGG) was present in 29.3% of the samples, and the remaining 4.0% of samples had mixed variants. The combination of A at nucleotide (nt) 1762 and G at nt 1764 of the core promoter was found in 58.7% of the samples. The variant profiles-T at nt 1762 and A at nt 1764 or A at nt 1762 and A at nt 1764-were detected in 28.0 and 1.3% of the samples, respectively. The observed core promoter polymorphisms could not be related to the ratio of HBeAg to anti-HBeAg antibody, HBV genotype, or precore codon 28 status. Nevertheless, a clear association of genotype F and a precore stop codon mutation was found (P < 0.05). In conclusion, HBV genotype F and mutant codon 28 strains predominated and were strongly associated in a geographically broad Argentinean blood donor population.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Strong Association between Genotype F and Hepatitis B Virus (HBV) e Antigen-Negative Variants among HBV-Infected Argentinean Blood Donors

et al. 2004

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“…Later research has identified another four HBV genotypes, E-H [2][3][4][5][6]. Two genotypes, A and F, have been further subdivided into subgenotypes identified by arabic numerals [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Hepatitis B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HB<sub>s</sub>Ag Subtypes

et al. 2004

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Sequences of 234 complete genomes and 631 hepatitis B surface antigen genes were used to assess the worldwide diversity of hepatitis B virus (HBV). Apart from the described two subgenotypes each for A and F, also B, C, and D divided into four subgenotypes each in the analysis of complete genomes supported by significant bootstrap values. The subgenotypes of B and C differed in their geographical distribution, with B1 dominating in Japan, B2 in China and Vietnam, B3 confined to Indonesia, and B4 confined to Vietnam, all strains specifying subtype ayw1. Subgenotype C1 was common in Japan, Korea, and China; C2 in China, South-East Asia, and Bangladesh, and C3 in the Oceania comprising strains specifying adrq–, and C4 specifying ayw3 is encountered in Aborigines from Australia. This pattern of defined geographical distribution was less evident for D1–D4, where the subgenotypes were widely spread in Europe, Africa, and Asia, possibly due to their divergence having occurred a longer time ago than for genotypes B and C, with D4 being the first split and still the dominating subgenotype of D in the Oceania. The genetic diversity of HBV and the geographical distribution of its subgenotypes provide a tool to reconstruct the evolutionary history of HBV and may help to complement genetic data in the understanding of the evolution and past migrations of man.

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Viral Hepatitis

Rizzetto¹,

Zoulim²

2007

Textbook of Hepatology

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The T1858 variant predisposing to the precore stop mutation correlates with one of two major genotype F hepatitis B virus clades

Cited by 43 publications

References 32 publications

Strong Association between Genotype F and Hepatitis B Virus (HBV) e Antigen-Negative Variants among HBV-Infected Argentinean Blood Donors

Strong Association between Genotype F and Hepatitis B Virus (HBV) e Antigen-Negative Variants among HBV-Infected Argentinean Blood Donors

Genetic Diversity of Hepatitis B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HB<sub>s</sub>Ag Subtypes

Viral Hepatitis

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