The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients

Kottaridi, Christine; Resta, Panagiota; Leventakou, Danai; Gioti, Katerina; Zygouras, Ioannis; Gouloumi, Alina-Roxani; Sakagiannis, Georgios; Alzahrani, Khalid J.; Venetikou, Maria S.; Anthouli-Anagnostopoulou, Fragkiski; Beloukas, Apostolos

doi:10.3390/v14081724

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Conversely, an Italian study reported a prevalence of 19.6% for African HPV16 variants in HNSCC samples, highlighting their relevance in the head and neck anatomical tumor site [30]. As seen before in CC studies, when focusing on specific viral genome regions, such as the E6 gene, the most frequent polymorphism reported in a small cohort of HNSCCs was T350G [35,37]. However, this finding needs further investigation to determine its impact on clinical outcomes.…”

Section: Hpv16 Variants and Head And Neck Tumormentioning

confidence: 86%

“…A study conducted in Greece showed that 85% of HPV16 sequences detected in 40 specimens from subjects with HNSCC were clustered into the European sublineage A3, while the remaining 15% of HPV16 variants were related to sublineage D1 [ 35 ]. In another study on HPV16–positive OPSCCs performed in the USA, the A1 sublineage was associated with poor recurrence-free survival (RFS) [ 87 ].…”

Section: Hpv16 Variants and Head And Neck Tumormentioning

confidence: 99%

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HPV16 Phylogenetic Variants in Anogenital and Head and Neck Cancers: State of the Art and Perspectives

Galati,

Di Bonito,

Marinaro

et al. 2024

Viruses

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HPV16 is responsible for approximately 60% and 90% of global HPV–induced cervical and oropharyngeal cancers, respectively. HPV16 intratype variants have been identified by HPV genome sequencing and classified into four phylogenetic lineages (A–D). Our understanding of HPV16 variants mostly derives from epidemiological studies on cervical cancer (CC) in which HPV16 B, C, and D lineages (previously named “non-European” variants) were mainly associated with high-grade cervical lesions and cancer. Although a predominance of HPV16 lineage A (previously named “European variants”) has been observed in head and neck squamous cell carcinoma (HNSCC), epidemiological and in vitro biological studies are still limited for this tumor site. Next Generation Sequencing (NGS) of the entire HPV genome has deepened our knowledge of the prevalence and distribution of HPV variants in CC and HNSCC. Research on cervical cancer has shown that certain HPV16 sublineages, such as D2, D3, A3, and A4, are associated with an increased risk of cervical cancer, and sublineages A4, D2, and D3 are linked to a higher risk of developing adenocarcinomas. Additionally, lineage C and sublineages D2 or D3 of HPV16 show an elevated risk of developing premalignant cervical lesions. However, it is still crucial to conduct large-scale studies on HPV16 variants in different HPV–related tumor sites to deeply evaluate their association with disease development and outcomes. This review discusses the current knowledge and updates on HPV16 phylogenetic variants distribution in HPV–driven anogenital and head and neck cancers.

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Section: Hpv16 Variants and Head And Neck Tumormentioning

confidence: 86%

Section: Hpv16 Variants and Head And Neck Tumormentioning

confidence: 99%

HPV16 Phylogenetic Variants in Anogenital and Head and Neck Cancers: State of the Art and Perspectives

Galati,

Di Bonito,

Marinaro

et al. 2024

Viruses

View full text Add to dashboard Cite

show abstract

“…Work on hepatocyte biochemistry revealed that HCV and dengue virus, another hepatotropic virus, replication is associated with catecholamine biosynthesis [ 12 , 13 ]. The Special Issue concluded with the growing importance of HPV variants, such as the T350G variant, in the understudying of the pathobiology of oropharyngeal cancer [ 14 ], as well as the assessment of the prevalence rates of common viruses, such as papilloma, herpes, and pox viruses, on the skin of beach volley athletes [ 15 ].…”

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confidence: 99%