The Tachykinin Peptide Family, with Particular Emphasis on Mammalian Tachykinins and Tachykinin Receptor Agonists

Conlon, J. M.

doi:10.1007/978-3-642-18891-6_2

Cited by 6 publications

(8 citation statements)

References 221 publications

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“…This C-terminally amidated sequence is of primary importance for the interaction with the tachykinin receptors (Conlon, 2004). In mammals, SP, NKA, NPγ, and neuropeptide K (NPK) are encoded by the single copy preprotachykinin A gene.…”

Section: Effects Of Intracerebroventricular Injections Of Neuropeptidesmentioning

confidence: 99%

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

et al. 2012

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Many neuropeptides and their G-protein coupled receptors (GPCRs) are present within the brain area involved in ventilatory and cardiovascular regulation but only a few mammalian studies have focused on the integrative physiological actions of neuropeptides on these vital cardio-respiratory regulations. Because both the central neuroanatomical substrates that govern motor ventilatory and cardiovascular output and the primary sequence of regulatory peptides and their receptors have been mostly conserved through evolution, we have developed a trout model to study the central action of native neuropeptides on cardio-ventilatory regulation. In the present review, we summarize the most recent results obtained using this non-mammalian model with a focus on PACAP, VIP, tachykinins, CRF, urotensin-1, CGRP, angiotensin-related peptides, urotensin-II, NPY, and PYY. We propose hypotheses regarding the physiological relevance of the results obtained.

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Section: Effects Of Intracerebroventricular Injections Of Neuropeptidesmentioning

confidence: 99%

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

et al. 2012

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“…The data indicate that NP␥ was about fivefold more potent than SP and NKA in producing an elevation of f V, a reduction of V AMP , and an overall hypoventilatory response. The N-terminal extension to the NKA sequence in NP␥ is not considered to be involved in receptor interaction (see Conlon, 2004) increased stability within the third ventricle relative to NKA and SP.…”

Section: Ventilatory and Cardiovascular Actions Of Centrally Administmentioning

confidence: 99%

“…Further studies are needed to clarify this issue. The effects of the tachykinins on the peripheral cardiovascular system in trout stand in sharp contrast with the effects of NP␥, SP and NKA in mammals, where the three peptides are potent vasodilators of several vascular beds (see Conlon, 2004;Walsh and McWilliams, 2006). In the anesthetized guinea pig, intravenous injection of NP␥ produced a fall in blood pressure that was mediated through interaction with NK-1 receptors, together with an increase in total pulmonary resistance and decrease in dynamic lung compliance that were mediated through NK-2 receptors (Yuan et al, 1994).…”

Section: Ventilatory and Cardiovascular Actions Of Intraarteriallymentioning

confidence: 99%

“…In mammals, substance P (SP), neurokinin A (NKA), neuropeptide gamma (NP␥) and neuropeptide K (NPK) are encoded by the single copy preprotachykinin A gene. Neurokinin B is derived from the preprotachykinin B gene while the preprotachykinin C gene encodes three peptides (hemokinin 1, endokinin C and endokinin D), with limited structural similarity with SP (see Conlon, 2004). The tachykinins exert their actions by binding to G-protein coupled receptors that are widely distributed within vascular, endocrine and nervous tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Holzer, 2006;Page, 2006;Walsh and McWilliams, 2006). Orthologs of the mammalian tachykinins have been isolated and structurally characterized in a wide range of tetrapod and non-tetrapod species (see Conlon, 2004). In particular, SP (Jensen and Conlon, 1992), NKA (Jensen and Conlon, 1992) and NP␥ (Jensen et al, 1993) have been purified from tissues of the rainbow trout Oncorhynchus mykiss.…”

Section: Introductionmentioning

confidence: 99%

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Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized trout

Mével

Lancien

Mimassi

et al. 2007

Journal of Experimental Biology

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SUMMARY The brains of teleost fish contain members of the tachykinin family that are the products of orthologous genes expressed in mammalian nervous tissues,but little is known regarding the physiological effects of these peptides in their species of origin. The present study compares the central actions of trout neuropeptide gamma (NPγ), substance P (SP) and neurokinin A (NKA)(5–250 pmol) on ventilatory and cardiovascular parameters in the unanesthetized rainbow trout Oncorhynchus mykiss. Intracerebroventricular (ICV) injection of NPγ evoked a dose-dependent elevation of the ventilation rate (fV) but a reduction of the ventilation amplitude (VAMP) that was caused by a reduction of the magnitude of the adduction phase of the ventilatory signal. The net effect of NPγ was to produce an hypoventilatory response since the total ventilation (VTOT) was significantly reduced. The minimum effective dose for a significant effect of NPγ on fV and VAMP was 50 pmol. SP evoked a significant elevation of fV, a concomitant depression of VAMP, and a resultant decrease in VTOTbut only at the highest dose (250 pmol). NKA was without action on fV but significantly decreased VAMP at only the highest dose tested. In this case also, the net effect of NKA was to reduce VTOT. When injected centrally, none of the three peptides, at any dose tested, produced changes in heart rate or mean dorsal aortic blood pressure (PDA). Intra-arterial injection of the three tachykinins (250 pmol) produced a significant (P<0.05)increase in PDA, but only SP and NKA induced concomitant bradycardia. None of the three peptides produced any change in fV or VAMP. In conclusion, our results demonstrate that centrally injected tachykinins, particularly NPγ,produce a strong hypoventilatory response in a teleost fish and so suggest that endogenous tachykinins may be differentially implicated in neuroregulatory control of ventilation.

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Hemodynamic effects of python neuropeptide γ in the anesthetized python, Python regius

Skovgaard

Galli

Taylor

et al. 2005

Regulatory Peptides

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The Tachykinin Peptide Family, with Particular Emphasis on Mammalian Tachykinins and Tachykinin Receptor Agonists

Cited by 6 publications

References 221 publications

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized trout

Hemodynamic effects of python neuropeptide γ in the anesthetized python, Python regius

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