The Tail Suspension Test

Can, Adem; Dao, David; Terrillion, Chantelle E.; Piantadosi, Sean C.; Bhat, Shambhu; Gould, Todd D.

doi:10.3791/3769-v

Cited by 137 publications

(65 citation statements)

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“…Both C57BL/6J and BALB/c mice, which were subjected to social isolation stress, were used in the experiments ( Figure 1 ). The tail suspension test (TST) is the most-common method of evaluating the depression behavior in experimental animals [ 21 ]. When mice are suspended in midair with their tails fixed, they behave as if they are resisting the condition.…”

Section: Resultsmentioning

confidence: 99%

Matcha Tea Powder’s Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress

et al. 2023

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Matcha tea powder is believed to have various physiological benefits; however, its detailed mechanism of action has been poorly understood. Here, we investigated whether the mental state of mice, due to social isolation stress, affects the antidepressant-like effect of Matcha tea powder by using the tail suspension test. Oral administration of Matcha tea powder reduced the duration of immobility in the stress-susceptible C57BL/6J strain, but not in BALB/c strain. In C57BL/6J mice, SCH23390, a dopamine D1 receptor blocker, prevented Matcha tea powder from exerting its antidepressant-like effect. Matcha tea powder also increased the number of c-Fos-positive cells in the prefrontal cortex (PFC) region and the nucleus accumbens (NAc) region in C57BL/6J mice, but not in BALB/c mice. In contrast, Matcha tea powder did not change the number of c-Fos-positive cells in the ventral tegmental area (VTA) region. Notably, C57BL/6J mice with a shorter immobility time had a higher number of c-Fos-positive cells in the PFC, NAc, and VTA regions. However, no such correlation was observed in the stress-tolerant BALB/c mice. These results suggest that Matcha tea powder exerts an antidepressant-like effect through the activation of the dopaminergic system including the PFC-NAc-VTA circuit and that mental states are important factors affecting the physiological benefits of Matcha tea powder.

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Section: Resultsmentioning

confidence: 99%

Matcha Tea Powder’s Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress

et al. 2023

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“…Nest building test (NBT), 42–44 tail suspension test (TST), 45–47 forced swim test (FST) 48–50 and the elevated plus maze (EPM) 51,52 were used to evaluate the effect of the test compounds on the different groups. Animals treated with the standard drug sertraline built nests enveloping the animal, whereas animals from the vehicle group did not engage in nest-building activity or built flat nests.…”

Section: Resultsmentioning

confidence: 99%

“…Unpredictable chronic mild stress adapted from Burstein et al was used for assessing the anti-depressant potential of the target compounds (BM212 and SA-5). 40,41 Nest building test (NBT), [42][43][44] tail suspension test (TST), [45][46][47] forced swim test (FST) [48][49][50] and the elevated plus maze (EPM) 51,52 were used to evaluate the effect of the test compounds on the different groups. Animals treated with the standard drug sertraline built nests enveloping the animal, whereas animals from the vehicle group did not engage in…”

Section: In Vivo Studiesmentioning

confidence: 99%

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Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1H-pyrrol-3-yl)-N-methylmethanamines as SERT inhibitors with potential antidepressant action

et al. 2023

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“…Mice were acclimated to the experimental room for at least 30 min before the test. Mending tape was applied approximately 2 cm from the tail end of the mouse, the tape was fixed to the horizontal bar of the behavioural apparatus, and the mouse was suspended for 6 min [ 28 ]. The behavioural experiment was recorded and the custom-made Bonsai workflow was used to annotate the moving time and calculate the immobility time [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Chronic corticosterone deteriorates latrine and nesting behaviours in mice

Nomoto

Kansaku

2023

R. Soc. open sci.

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Self-care behaviours are actions that help maintain good health and surroundings. For example, appropriate toileting, sleeping in the bed, and bathing and washing are among self-care behaviours in humans. Animals also perform similar self-care behaviours such as latrine, nesting and self-grooming. Studies have shown that chronic stress disrupts nesting and self-grooming behaviours. However, the effect of chronic stress on latrine behaviour, preferential, repeated defecation at specific locations, has not yet been clarified. This study aimed to investigate the influence of chronic corticosterone administration on latrine and nesting behaviours in mice. The variation in defecation location was quantified as the degree of the latrine behaviour by using Shannon entropy. The nest quality was scored based on shape. The study showed that mice exposed to chronic corticosterone had scattered defecation sites and lower nest quality compared to the control group. Furthermore, results showed that more scattered defecation behaviour was associated with lower nest quality at an individual level. Additionally, the deterioration of these self-care behaviours was associated with depression-like behaviours such as less open field activity and increased immobility time during the tail suspension test. These results suggest that chronic corticosterone deteriorates self-care behaviours such as latrine and nesting in mice.

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The Tail Suspension Test

Cited by 137 publications

References 0 publications

Matcha Tea Powder’s Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress

Matcha Tea Powder’s Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress

Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1H-pyrrol-3-yl)-N-methylmethanamines as SERT inhibitors with potential antidepressant action

Chronic corticosterone deteriorates latrine and nesting behaviours in mice

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