The Tako-Tsubo syndrome: No evidence of peripheral endothelial or microvascular dysfunction

Coronary microvascular function in Takotsubo cardiomyopathy: Results of non-invasive evaluation

“…The report that CFR in 28 patients with significant incidence of comorbidities, such as hypertension in 39% and prior angina in 46%, compared to controls, was reduced not only during the acute phase of Takotsubo but also when LV wall motion alterations disappeared could suggest a most important role of concomitant diseases and coronary risk factors in the genesis of the decrease in CFR than the takotsubo disease itself [12]. Our results seem in accord with those of Salerno et al that find no evidence of peripheral endothelial or microvascular dysfunction in the acute phase of Takotsubo disease in a 73-year-old woman [13].…”

Changes in endothelial function in healthy volunteers during soccer World Cup 2010 games

“…For instance, we recently showed that an impaired L-FMC in the presence of a preserved FMD characterizes the coronary slow flow phenomenon [6], a condition where resting coronary resistances, but not microvascular reactivity, are abnormal. As well, emotional stress is a known trigger for the Tako-Tsubo cardiomyopathy [7,8], which was also associated with impaired L-FMC and preserved FMD in a case report [9]. The present data suggest that, even in young healthy individuals, emotional stress associated with a sport watching may cause endothelial dysfunction.…”