The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy

Huang, Peng; Wen, Feng; Li, YiShan; Li, Qiu

doi:10.1016/j.lfs.2024.122576

Cited by 7 publications

(3 citation statements)

References 157 publications

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“…LncRNAs exert an important role in the onset and advancement of HCC by modulating ferroptosis [ 38 , 133 ]. It is evident that lncRNAs are involved in the activities of cell proliferation, invasion, EMT and tumor growth [ 30 , 99 ]. Therefore, lncRNAs have potential prospects for clinical application as biomarkers for the diagnosis, treatment, recurrence, and prognosis of HCC.…”

Section: Ferroptosis-related Lncrnas In Hcc Progression and Prognosismentioning

confidence: 99%

“…Long noncoding RNAs (lncRNAs) constitute a diverse category of non‐protein‐coding transcripts with lengths exceeding 200 nucleotides [ 30 ]. LncRNAs serve as emerging regulators involved in various cellular events including chromatin remodeling, transcriptional regulation, and epigenetic modification, which affect a wide range of physiological and pathological processes [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Jin,

Huang,

Tian

2024

Clin Exp Med

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Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form of regulated cell death, possesses distinct morphological, biochemical, and genetic characteristics compared to other types of cell death. Dysregulated actions within the molecular network that regulates ferroptosis have been identified as significant contributors to the progression of HCC. Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse cellular processes, regulating gene function and expression through multiple mechanistic pathways. An increasing body of evidence indicates that deregulated lncRNAs are implicated in regulating malignant events such as cell proliferation, growth, invasion, and metabolism by influencing ferroptosis in HCC. Therefore, elucidating the inherent role of ferroptosis and the modulatory functions of lncRNAs on ferroptosis in HCC might promote the development of novel therapeutic interventions for this disease. This review provides a succinct overview of the roles of ferroptosis and ferroptosis-related lncRNAs in HCC progression and treatment, aiming to drive the development of promising therapeutic targets and biomarkers for HCC patients.

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Section: Ferroptosis-related Lncrnas In Hcc Progression and Prognosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Jin,

Huang,

Tian

2024

Clin Exp Med

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“…Furthermore, lncRNAs orchestrate tumorigenesis and metastasis in diverse malignancies, including HCC, by perturbing gene expression at the transcriptional or epigenetic level (Abbastabar et al 2018 ; Yao et al 2022 ). Multiple lncRNAs have been reported to regulate lung cancer growth and metastasis (Huang et al 2021b , 2024 ). The lncRNA ANCR exhibited heightened expression in both HCC tissues and cells, displaying a positive association with tumor differentiation, TNM stage, tumor size, and the presence of portal vein tumor thrombus (Wen et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway

Luo,

Zhuang,

Huang

et al. 2024

J Cancer Res Clin Oncol

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Purpose Long noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with RNAs. Among these, lncRNA ZFAS1 has been implicated in oncogenic roles in multiple cancer types. Nevertheless, the intricate biological significance and underlying mechanism of ZFAS1 in the initiation and progression of hepatocellular carcinoma (HCC) remain largely unexplored. Methods Analysis of The Cancer Genome Atlas Program (TCGA) database revealed a notable upregulation of lncRNA ZFAS1 in HCC tissues. To explore its function, we investigated colony formation and performed CCK-8 assays to gauge cellular proliferation and wound healing, Transwell assays to assess cellular migration, and an in vivo study employing a nude mouse model to scrutinize tumor growth and metastasis. Luciferase reporter assay was used to confirm the implicated interactions. Rescue experiments were conducted to unravel the plausible mechanism underlying the activation of the PI3K/AKT pathway by lncRNAs ZFAS1 and ATIC. Results ZFAS1 and ATIC were significantly upregulated in the HCC tissues and cells. ZFAS1 knockdown inhibited cell proliferation and migration. We observed a direct interaction between the lncRNA ZFAS1 and ATIC. ATIC knockdown also suppressed cell proliferation and migration. SC79, an activator of AKT, partially restores the effects of lncRNA ZFAS1/ATIC knockdown on cell proliferation and migration. Knockdown of lncRNA ZFAS1/ATIC inhibited tumor growth and lung metastasis in vivo. Conclusion Overall, lncRNA ZFAS1 regulates ATIC transcription and contributes to the growth and migration of HCC cells through the PI3K/AKT signaling pathway.

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Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study

Lee,

Chen,

Tsai

et al. 2024

J Cancer Res Clin Oncol

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Background Patients with autoimmune diseases (AD) generally carry an increased risk of developing cancer. However, the effect of AD in hepatocellular carcinoma (HCC) patients receiving surgical treatment is uncertain. The present study aimed to investigate the potential influence of AD on the survival of HCC patients undergoing hepatectomies. Methods Operated HCC patients were identified from the Chang Gung Research Database, and the survival outcomes of HCC patients with or without AD were analyzed ad compared. Cox regression model was performed to identify significant risk factors associated with disease recurrence and mortality. Results From 2002 to 2018, a total of 5532 patients underwent hepatectomy for their HCC. Among them, 229 patients were identified to have AD and 5303 were not. After excluding cases who died within 30 days of surgery, the estimated median overall survival (OS) was 43.8 months in the AD (+) group and 47.4 months in the AD (–) group (P = 0.367). The median liver-specific survival and disease-free survival (DFS) were also comparable between the two groups. After Cox regression multivariate analysis, the presence of AD did not lead to a higher risk of all-cause mortality, liver-specific mortality, or disease recurrence. Conclusion Our study demonstrated that autoimmune disease does not impair the OS and DFS of HCC patients undergoing liver resections. AD itself is not a risk factor for tumor recurrence after surgery. Patients eligible for liver resections, as a result, should be considered for surgery irrespective of the presence of AD. Further studies are mandatory to validate our findings.

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The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy

Cited by 7 publications

References 157 publications

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway

Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study

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