The target gene of tae‐<scp>miR164</scp>, a novel <scp>NAC</scp> transcription factor from the <scp>NAM</scp> subfamily, negatively regulates resistance of wheat to stripe rust

Hu, Feng; Duan, Xiyu; Zhang, Qiong; Li, Xiaorui; Wang, Bing; Huang, Lili; Wang, Xiaojie; Kang, Zhensheng

doi:10.1111/mpp.12089

Cited by 152 publications

(100 citation statements)

References 56 publications

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“…Lateral root development also is influenced by the miR164-NAC1 pathway (Guo et al, 2005), and miR164 negatively regulates pathogen-induced and age-dependent cell death by target NAC4 (Lee et al, 2017) and ORE1/NAC2 (Kim et al, 2009), respectively. Similar functions of miR164 and its effect on NAC transcription factors also have been reported in rice (drought resistance; Fang et al, 2014), wheat (resistance to stripe rust; Feng et al, 2014) and Medicago truncatula (root; D'Haeseleer et al, 2011). Similar functions of miR164 and its effect on NAC transcription factors also have been reported in rice (drought resistance; Fang et al, 2014), wheat (resistance to stripe rust; Feng et al, 2014) and Medicago truncatula (root; D'Haeseleer et al, 2011).…”

Section: Discussionsupporting

confidence: 67%

Genome‐wide analysis of coding and non‐coding RNA reveals a conserved miR164‐NAC regulatory pathway for fruit ripening

Wang

et al. 2019

New Phytologist

104

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Summary Kiwifruit (Actinidia spp.) is a climacteric fruit with high sensitivity to ethylene, influenced by multiple ethylene‐responsive structural genes and transcription factors. However, the roles of other post‐transcriptional regulators (e.g. miRNAs) necessary for ripening remain elusive. High‐throughput sequencing sRNAome, degradome and transcriptome methods were used to identify further contributors to ripening control in the kiwifruit (A. deliciosa cv ‘Hayward’). Two NAM/ATAF/CUC domain transcription factors (AdNAC6 and AdNAC7), both predicted targets for miR164, showed significant upregulation by exogenous ethylene. Gene expression analysis and luciferase reporter assays indicated that Ade‐miR164 and one of its precursor miRNAs (Ade‐MIR164b) were repressed by ethylene treatment and negatively correlated with AdNAC6/7 expression. Subsequent analysis indicated that both AdNAC6 and AdNAC7 proteins are transcriptional activators and physically bind the promoters of AdACS1 (1‐aminocyclopropane‐1‐carboxylate synthase), AdACO1 (1‐aminocyclopropane‐1‐carboxylic acid oxidase), AdMAN1 (endo‐β‐mannanase) and AaTPS1 (terpene synthase). Moreover, subcellular analysis indicated that the location of the AdNAC6/7 proteins was influenced by Ade‐miR164. Multiple omics‐based approaches revealed a novel regulatory link for fruit ripening that involved ethylene‐miR164‐NAC. The regulatory pathway for miR164‐NAC is present in various fruit (e.g. Rosaceae fruit, citrus, grape), with implications for fruit ripening regulation.

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Section: Discussionsupporting

confidence: 67%

Genome‐wide analysis of coding and non‐coding RNA reveals a conserved miR164‐NAC regulatory pathway for fruit ripening

Wang

et al. 2019

New Phytologist

104

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“…Furthermore, ONAC60 is targeted by miR164 in rice (Wu et al 2009b). Additionally, a recent study from Feng and colleagues showed miR164 regulation of TaNAC21/22 gene under infection by wheat stripe rust (Feng et al 2014). This study supports a NAC/miRNA association under stress in a member of the Triticeae .…”

Section: Mirna and Stress Regulation Mechanismsmentioning

confidence: 99%

Abiotic stress miRNomes in the Triticeae

Alptekin

Langridge

Budak

2016

Funct Integr Genomics

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The continued growth in world population necessitates increases in both the quantity and quality of agricultural production. Triticeae members, particularly wheat and barley, make an important contribution to world food reserves by providing rich sources of carbohydrate and protein. These crops are grown over diverse production environments that are characterized by a range of environmental or abiotic stresses. Abiotic stresses such as drought, heat, salinity, or nutrient deficiencies and toxicities cause large yield losses resulting in economic and environmental damage. The negative effects of abiotic stresses have increased at an alarming rate in recent years and are predicted to further deteriorate due to climate change, land degradation, and declining water supply. New technologies have provided an important tool with great potential for improving crop tolerance to the abiotic stresses: microRNAs (miRNAs). miRNAs are small regulators of gene expression that act on many different molecular and biochemical processes such as development, environmental adaptation, and stress tolerance. miRNAs can act at both the transcriptional and post-transcriptional levels, although post-transcriptional regulation is the most common in plants where miRNAs can inhibit the translation of their mRNA targets via complementary binding and cleavage. To date, expression of several miRNA families such as miR156, miR159, and miR398 has been detected as responsive to environmental conditions to regulate stress-associated molecular mechanisms individually and/or together with their various miRNA partners. Manipulation of these miRNAs and their targets may pave the way to improve crop performance under several abiotic stresses. Here, we summarize the current status of our knowledge on abiotic stress-associated miRNAs in members of the Triticeae tribe, specifically in wheat and barley, and the miRNA-based regulatory mechanisms triggered by stress conditions. Exploration of further miRNA families together with their functions under stress will improve our knowledge and provide opportunities to enhance plant performance to help us meet global food demand.

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“…A number of miRNA families have now been identified in wheat, and about twenty miRNA families are conserved in diverse plant species (Yao et al, 2007;Feng et al, 2014;Han et al, 2014;Kumar et al, 2014;Sun et al, 2014). Of these, miR408 contains 21 nucleotides and has been annotated in more than 30 plant species to date, indicating a high level of conservation in different plant species (Axtell and Bowman, 2008;Kozomara and Griffiths-Jones, 2011).…”

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confidence: 99%

The tae-miR408-Mediated Control of TaTOC1 Genes Transcription Is Required for the Regulation of Heading Time in Wheat

Zhao

Hong

et al. 2016

Plant Physiol.

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ORCID IDs: 0000-0002-1560-7935 (J.Y.W.); 0000-0002-3129-5206 (X.S.Z.).Timing of flowering is not only an interesting topic in developmental biology, but it also plays a significant role in agriculture for its effects on the maturation time of seed. The hexaploid wheat (Triticum aestivum) is one of the most important crop species whose flowering time, i.e. heading time, greatly influences yield. However, it remains unclear whether and how microRNAs regulate heading time in it. In our current study, we identified the tae-miR408 in wheat and its targets in vivo, including Triticum aestivum TIMING OF CAB EXPRESSION-A1 (TaTOC-A1), TaTOC-B1, and TaTOC-D1. The tae-miR408 levels were reciprocal to those of TaTOC1s under long-day and short-day conditions. Wheat plants with a knockdown of TaTOC1s via RNA interference and overexpression of tae-miR408 showed early-heading phenotype. Furthermore, TaTOC1s expression was down-regulated by the tae-miR408 in the hexaploid wheat. In addition, other important agronomic traits in wheat, such as plant height and flag leaf angle, were regulated by both tae-miR408 and TaTOC1s. Thus, our results suggested that the tae-miR408 functions in the wheat heading time by mediating TaTOC1s expression, and the study provides important new information on the mechanism underlying heading time regulation in wheat.

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The target gene of tae‐miR164, a novel NAC transcription factor from the NAM subfamily, negatively regulates resistance of wheat to stripe rust

Cited by 152 publications

References 56 publications

Genome‐wide analysis of coding and non‐coding RNA reveals a conserved miR164‐NAC regulatory pathway for fruit ripening

Genome‐wide analysis of coding and non‐coding RNA reveals a conserved miR164‐NAC regulatory pathway for fruit ripening

Abiotic stress miRNomes in the Triticeae

The tae-miR408-Mediated Control of TaTOC1 Genes Transcription Is Required for the Regulation of Heading Time in Wheat

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