The target of vasovagal syncope is hemostasis and not heart protection

Diehl, Rolf R.

doi:10.1007/s10286-017-0450-6

Clin Auton Res

2017

DOI: 10.1007/s10286-017-0450-6

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The target of vasovagal syncope is hemostasis and not heart protection

Rolf R. Diehl

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Cited by 2 publications

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“…Many factors can trigger vasovagal syncope, including orthostatic, blood loss, and situational factors such as emotional stress, dehydration, pain, and hyperventilation [3]. Moreover, there is a limited understanding of some of the physiological mechanisms and a lack of consensus regarding its origins and adaptive functions [4,5]. Even the term "vasovagal" also implies a mechanism that involves both vagal activity and vasodilation.…”

mentioning

confidence: 99%

Sleep syncope: a new clinical entity or just a vasovagal syncope during wakefulness after sleep onset?

Gilchrist

Provini

2022

Clin Auton Res

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mentioning

confidence: 99%

Sleep syncope: a new clinical entity or just a vasovagal syncope during wakefulness after sleep onset?

Gilchrist

Provini

2022

Clin Auton Res

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Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice

et al. 2023

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Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because preclinical evidence shows electrical vagus nerve stimulation accelerates clotting to reduce hemorrhage without precipitating systemic thrombosis, we reasoned it might reduce bleeding in hemophilia A. Using two different male murine hemorrhage and thrombosis models, we show vagus nerve stimulation bypasses the factor VIII deficiency of hemophilia A to decrease bleeding and accelerate clotting. Vagus nerve stimulation targets acetylcholine-producing T lymphocytes in spleen and α7 nicotinic acetylcholine receptors (α7nAChR) on platelets to increase calcium uptake and enhance alpha granule release. Splenectomy or genetic deletion of T cells or α7nAChR abolishes vagal control of platelet activation, thrombus formation, and bleeding in male mice. Vagus nerve stimulation warrants clinical study as a therapy for coagulation disorders and surgical or traumatic bleeding.

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The target of vasovagal syncope is hemostasis and not heart protection

Cited by 2 publications

References 14 publications

Sleep syncope: a new clinical entity or just a vasovagal syncope during wakefulness after sleep onset?

Sleep syncope: a new clinical entity or just a vasovagal syncope during wakefulness after sleep onset?

Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice

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