The targeted anti-Salmonella bacteriophage attenuated the inflammatory response of laying hens challenged with Salmonella Gallinarum

Hosseindoust, Abdolreza; Ha, SangHun; Lokhande, Anushka; Mun, JunYoung; Kim, Young In; Kim, JinSoo

doi:10.1016/j.psj.2022.102296

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…The spleen is the main immune organ, and it plays important roles in filtering blood-borne pathogens and antigens to protect the host against various infectious diseases and pathogen infections [ 29 , 30 , 31 ]. Herein, the spleen is regarded as the ideal organ model for exploring host resistance and susceptibility to pathogenic challenges.…”

Section: Introductionmentioning

confidence: 99%

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Yan

Wang

Yang

et al. 2023

CIMB

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LncRNAs play important roles in resisting bacterial infection via host immune and inflammation responses. Clostridium perfringens (C. perfringens) type C is one of the main bacteria causing piglet diarrhea diseases, leading to major economic losses in the pig industry worldwide. In our previous studies, piglets resistant (SR) and susceptible (SS) to C. perfringens type C were identified based on differences in host immune capacity and total diarrhea scores. In this paper, the RNA-Seq data of the spleen were comprehensively reanalyzed to investigate antagonistic lncRNAs. Thus, 14 lncRNAs and 89 mRNAs were differentially expressed (DE) between the SR and SS groups compared to the control (SC) group. GO term enrichment, KEGG pathway enrichment and lncRNA-mRNA interactions were analyzed to identify four key lncRNA targeted genes via MAPK and NF-κB pathways to regulate cytokine genes (such as TNF-α and IL-6) against C. perfringens type C infection. The RT-qPCR results for six selected DE lncRNAs and mRNAs are consistent with the RNA-Seq data. This study analyzed the expression profiling of lncRNAs in the spleen of antagonistic and sensitive piglets and found four key lncRNAs against C. perfringens type C infection. The identification of antagonistic lncRNAs can facilitate investigations into the molecular mechanisms underlying resistance to diarrhea in piglets.

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Section: Introductionmentioning

confidence: 99%

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Yan

Wang

Yang

et al. 2023

CIMB

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Integrated analysis of noncoding RNAs and mRNAs reveals their potential roles in chicken spleen response to Klebsiella variicola infection

Yin,

Shen,

Yin

et al. 2023

Research in Veterinary Science

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SalmoFree^® Phage Additive Proves Its Safety for Laying Hens

Hernández Villamizar,

Bonilla,

Jaramillo

et al. 2024

PHAGE

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The targeted anti-Salmonella bacteriophage attenuated the inflammatory response of laying hens challenged with Salmonella Gallinarum

Cited by 3 publications

References 27 publications

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Integrated analysis of noncoding RNAs and mRNAs reveals their potential roles in chicken spleen response to Klebsiella variicola infection

SalmoFree^® Phage Additive Proves Its Safety for Laying Hens

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The targeted anti-Salmonella bacteriophage attenuated the inflammatory response of laying hens challenged with Salmonella Gallinarum

Cited by 3 publications

References 27 publications

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen

Integrated analysis of noncoding RNAs and mRNAs reveals their potential roles in chicken spleen response to Klebsiella variicola infection

SalmoFree® Phage Additive Proves Its Safety for Laying Hens

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Product

Resources

About

SalmoFree^® Phage Additive Proves Its Safety for Laying Hens