The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles

Prucek, Robert; Tuček, Jiří; Kilianová, Martina; Panáček, Aleš; Kvı́tek, Libor; Filip, Jan; Kolář, Milan; Tománková, Kateřina; Zbořil, Radek

doi:10.1016/j.biomaterials.2011.03.039

Cited by 297 publications

(162 citation statements)

References 37 publications

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“…Although it was much higher than that against bacteria, it reveals that QOMA with certain concentration showed antifungal capacity. This observation is attributed to the distinction of cellular structure between bacteria and fungus [26,27]. The possible reason for this excellent antibacterial performance of QOMA is that QCS, OMMT and Ag NPs all possess antimicrobial activity.…”

Section: Antimicrobial Activity Of Qomamentioning

confidence: 99%

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

Chen

Cai³

et al. 2016

Journal of Experimental Nanoscience

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This work is aimed at developing a green antimicrobial coating. First, a green antimicrobial agent, quaternised chitosan (QCS)/organic montmorillonite (OMMT)/silver nanoparticles (Ag NPs) (QOMA) nanocomposite was fabricated through an environmental-friendly one-step approach. Morphological and structural characteristics of QOMA were investigated, and good antimicrobial activity was proved. QOMA was then incorporated into powder coating formulations to form a homogeneous coating on steel plates, which was studied by scanning electron images. Besides, the physical and mechanical properties as well as the antimicrobial performances of the coatings were discussed. The results showed that the addition of QOMA imparted good antimicrobial capacity to the powder coating, but did not affect its physical and mechanical properties. The coatings were able to effectively inactivate Gram-negative bacteria (Escherichia coli), Gram-positive bacteria (Staphylococcus aureus) and fungi (Aspergillus niger, Penicillium funiculosum, Chaetomium globasum, Paecilomyces varioti, Asp. terreus and Aureobasidium pullulans). Our findings demonstrate the possibilities of green antimicrobial coating containing QOMA for practical applications in medical devices, domestic appliances and other solid surfaces concerning bacterial infection and contamination.

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Section: Antimicrobial Activity Of Qomamentioning

confidence: 99%

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

Chen

Cai³

et al. 2016

Journal of Experimental Nanoscience

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“…16 Nevertheless, Ag NPs with a diameter less than 20 nm tend to aggregate, thereby reducing their antibacterial activity. 17 The second issue is the recovery of disinfectants in water environment. The Ag NPs are very small, which makes it difficult to eliminate them completely by centrifugation or filtration, and high concentrations of residual nanosilver in solution can cause potential adverse health effects.…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents

Wang

Zhang²,

Zhou³

et al. 2017

IJN

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Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe 3 O 4 @SiO 2 @Ag microflowers) were rationally designed and prepared to achieve strong bactericidal ability, a wide antimicrobial spectrum, and good recyclability. High-performance Fe 3 O 4 @SiO 2 @Ag microflowers served as a multifunction-supporting matrix and exhibited sufficient magnetic response property due to their 200 nm Fe 3 O 4 core. The microflowers also possessed a highly branched flower-like Ag shell that provided a large surface area for effective Ag ion release and bacterial contact. The modified-vancomycin layer was effectively bound to the cell wall of bacteria to increase the permeability of the cell membrane and facilitate the entry of the Ag ions into the bacterium, resulting in cell death. As such, the fabricated Van/Fe 3 O 4 @SiO 2 @Ag microflowers were predicted to be an effective and environment-friendly antibacterial agent. This hypothesis was verified through sterilization of Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus , with minimum inhibitory concentrations of 10 and 20 μg mL −1 , respectively. The microflowers also showed enhanced effect compared with bare Fe 3 O 4 @SiO 2 @Ag microflowers and free-form vancomycin, confirming the synergistic effects of the combination of the two components. Moreover, the antimicrobial effect was maintained at more than 90% after five cycling assays, indicating the high stability of the product. These findings reveal that Van/Fe 3 O 4 @SiO 2 @Ag microflowers exhibit promising applications in the antibacterial fields.

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“…3 In addition, iron oxide nanoparticles are promising candidates for drug delivery, 4 contrast enhancers in magnetic resonance imaging (mRI) medical diagnostics, 5 and are promising antimicrobial agents to combat bacteria resistant to conventional antibiotics. 6 Infections caused by antibiotic resistant microorganisms are increasing globally, reaching epidemic proportions. 7 Antimicrobial resistance to various classes of antibiotics is on the rise, with the emergence of multiple drug resistance among different microorganisms raising great concern in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities

Zowalaty¹,

Ali²,

Husseiny³

et al. 2015

IJN

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Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe 2+ and Fe 3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocomposites were subsequently characterized using X-ray diffraction and were evaluated for their antibacterial activity. The antimicrobial activity of the as-synthesized nanoparticles was evaluated using different Gram-positive and Gram-negative bacteria, as well as Mycobacterium tuberculosis . For the first time, it was found that the nanoparticles showed antimicrobial activities against the tested microorganisms (albeit with a more pronounced effect against Gram-negative than Gram-positive bacteria), and thus, should be further studied as a novel nano-antibiotic for numerous antimicrobial and antituberculosis applications. Moreover, since these nanoparticle bacteria fighters are magnetic, one can easily envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand. Due to the ability of magnetic nanoparticles to increase the sensitivity of imaging modalities (such as magnetic resonance imaging), these novel nanoparticles can also be used to diagnose the presence of such microorganisms. In summary, although requiring further investigation, this study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections.

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The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles

Cited by 297 publications

References 37 publications

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

Vancomycin-modified Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Ag microflowers as effective antimicrobial agents

The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities

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