Mission-oriented policies have been proposed for research and innovation in the European manufacturing industry to address grand challenges while fostering economic growth and employment. A mission is required to have clear goals that can be demonstrated also to a wide public, therefore research and innovation infrastructures play a key role to create the necessary conditions. Given the fundamental importance of public investment to promote innovation, possible funding mechanisms for industrial research and innovation are discussed. Furthermore, taking advantage of the experience gained during the Italian Flagship Project Factories of the Future, this chapter identifies three types of industrial research and innovation infrastructure that can support mission-oriented policies: lab-scale pilot plants, industrial-scale pilot plants, and lighthouse plants.