Human resource management system is an indispensable part of information strategy construction. Based on the theory of biological neural network, this paper constructs the strategic decision model of human resources management, then uses the micro-integration method to predict the demand for human resources, and solves the quantification problem of human resources supply prediction. In the simulation process, the model analyzes the current situation of the personnel management system and the necessity of research and plans and designs a computer-aided personnel management information system based on the Client/Server biological neural network structure. Personnel quality evaluation through the evaluation and analysis of the quality of the evaluated, to provide effective reference information for the enterprise personnel decision and index selection, the enterprise human resources allocation, use, training and development is of great significance. Neural networks rely on the powerful data storage, processing and computing capabilities of computers to help enterprises respond quickly to changes in external market conditions, improve the efficiency of decision-making, and create greater value for enterprises. Through experimental testing, it is found that when the iteration is 5, the network verification results have the best consistency. When the iterations reach 7, the standard of training target error set in this paper is reached. When the samples reached 60, the screening accuracy of the network reached 92.18%; when the samples increased to 80, the screening accuracy was further improved to 92.84%, indicating that the screening accuracy of the network increased with the training samples, which could be used to detect and classify samples quickly, objectively and accurately.