The tellurium-based immunomodulator, AS101 ameliorates adjuvant-induced arthritis in rats

Abstract

We report an anti‐rheumatic/inflammatory activity of the non‐toxic, tellurium‐based immunomodulatory compound AS101 in experimental RA by reducing disease progression, by blocking extravasation of inflammatory VLA4+ cells into the joint and by preservation of joint tissue architecture.

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

“…Moreover, the complexation of Schiff base ligands with metals, especially with tellurium (IV) metal has attracted researcher because of their wide range of applications, including their use as medicine, [25][26][27][28][29][30] chemical sensors, 31,32 porous materials and as a colorimetric probe for metal ion detection 33 because tellurium halides exhibit Lewis acid character and form stable chelates 34,35 with a variety of Schiff base ligands. The incorporation of tellurium (IV) metal ion into Schiff base ligands has been observed to enhance their bioactivities which demonstrated a broad spectrum of biological activities such as anthelminthic, 36 anti-tubercular, 37 immuno-modulatory 38 and antioxidant 39 etc. Additionally, these complexes have been utilized as catalysts [40][41][42] in various chemical reactions including redox enzymes, polymerization processes, epoxidation of olefins and electro-reduction of carbon dioxide.…”