The Temperature of Cavitation

Flint, Edward B.; Suslick, Kenneth S.

doi:10.1126/science.253.5026.1397

Cited by 1,089 publications

(502 citation statements)

References 27 publications

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“…39 Supporting this hypothesis, the addition of ultrasound contrast agent acting as artificial cavitation bubbles further increased transfection efficiency in the present in vivo study. The optimal ultrasound parameters for transfection such as sonication time, pressure, frequency, averaged intensity, and cavitation dose have not been systematically characterized.…”

Section: Discussionsupporting

confidence: 73%

Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery

et al. 2003

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The development of accurate, safe, and efficient gene delivery remains a major challenge towards the realization of gene therapeutic prevention and treatment of cardiovascular diseases. In this study, we investigated the ability of high-intensity focused ultrasound (HIFU), a form of mechanical wave transmission, to act as a noninvasive tool for the enhancement of in vivo gene transfer into rabbit carotid arteries. Segments of the common carotid arteries of New Zealand white rabbits were isolated and infused with plasmid DNA encoding the reporter b-galactosidase either with or without the addition of ultrasound contrast agent consisting of small (B2-5 mm) gasfilled human albumin microspheres to augment cavitation. Infused arteries were exposed to pulsed ultrasound for 1 min (frequency 0.85 MHz, burst length 50 ms, repetition frequency 1 Hz, duration 60 s, peak pressure amplitude of 15 MPa). At 6.3 MPa, HIFU enhanced gene expression eight-fold, and 17.5-fold in the presence of contrast. We found increasing amounts of b-galactosidase expression in the carotid vessel with increasing pressure amplitude. This dose-response relation was present with and without contrast. Without contrast, no vessel damage was detected up to 15 MPa, while the addition of contrast induced side effects above a threshold of 6.3 MPa peak pressure. The entire procedure was feasible and safe for the animals, and the results suggest that HIFU has the potential to assist in the noninvasive spatial regulation of gene transfer into the vascular system.

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Section: Discussionsupporting

confidence: 73%

Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery

et al. 2003

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“…The main mechanism of sonochemical was the formation of cavitation bubbles 31 , under certain conditions, some bubbles implode, generating very high temperatures and pressures, these transient, localized hot spots drive high-energy chemical reactions [32][33][34] .…”

Section: Resultsmentioning

confidence: 99%

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Bouasla¹,

Bechlem²,

Belhani³

et al. 2017

Orient. J. Chem

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A facile and versatile method for acylation of structurally diverse amines and sulfonamides under focused ultrasonic irradiation in catalyst-free and solvent-free conditions is reported. There are several advantages to this approach such as simple and easier workup conditions, small amount of time and high yielding. The acylation reaction was carried out with acetic anhydride. All structures of synthesized products have been identified by NMR and mass spectroscopy.

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“…multibubble SL). For SBSL the collapse is nearly spherically symmetric and highly reproducible (Brenner et al, 2002); and for MBSL the more frequent non repeatable asymmetric collapse produces liquid jets penetrating the hot bubble contents (Crum, 1994;Flint & Suslick, 1991;Matula & Roy, 1997;W.B. McNamara III, 2000).…”

Section: Introductionmentioning

confidence: 99%

Sonoluminescence and sonochemiluminescence from a microreactor

Rivas

Ashokkumar

Leong

et al. 2012

Ultrasonics Sonochemistry

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Micromachined pits on a substrate can be used to nucleate and stabilize microbubbles in a liquid exposed to an ultrasonic field. Under suitable conditions, the collapse of these bubbles can result in light emission (sonoluminescence, SL). Hydroxyl radicals (OH . ) generated during bubble collapse can react with luminol to produce light (sonochemiluminescence, SCL). SL and SCL intensities were recorded for several regimes related to the pressure amplitude (low and high acoustic power levels) at a given ultrasonic frequency (200 kHz) for pure water, and aqueous luminol and propanol solutions. Various arrangements of pits were studied, with the number of pits ranging from no pits (comparable to a classic ultrasound reactor), to three-pits. Where there was more than one pit present, in the high pressure regime the ejected microbubbles combined into linear (two-pits) or triangular (three-pits) bubble clouds (streamers). In all situations where a pit was present on the substrate, the SL was intensified and increased with the number of pits at both low and high power levels. For imaging SL emitting regions, Argon (Ar) saturated water was used under similar conditions. SL emission from aqueous propanol solution (50 mM) provided evidence of transient bubble cavitation. Solutions containing 0.1 mM luminol were also used to demonstrate the radical production by attaining the SCL emission regions.

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The Temperature of Cavitation

Cited by 1,089 publications

References 27 publications

Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery

Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Sonoluminescence and sonochemiluminescence from a microreactor

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